Projects formerly developed at IGS-CNRS | Weill Cornell Medicine

NORMA: normal mode fitting of crystal structures into EM densities using URO and NMA, presented at the EMBO Practical Course on Combination of Electron Microscopy and X-ray Crystallography in Structure Determination, Gif s/Yvette, France, 2005.
Implementation of a Web-tool for protein normal mode analysis (NMA) using the elastic network model approximation (Tirion, 1996).
We show three examples where NMA can be used to break difficult molecular replacement problems.
At the example of the E. coli membrane channel proteins, we show how NMA can identify putative channel opening/closure conformational changes.
REF1: Suhre and Sanejouand, Acta Cryst. D, 2004.
REF2: Suhre and Sanejouand, NAR, 2004.
REF3: Suhre, Sanejouand, Navaza, Acta Cryst. D, 2006.

The Elastic Network Model