CCMetrics and ACCMetrics

CCMetrics and ACCMetrics are validated image analysis software for manual and automated tracing of corneal nerve morphology for three CCM measures:

  • Corneal nerve fiber density (CNFD) (fibers/mm2)
  • Corneal nerve branch density (CNBD) (branches/mm2)
  • Corneal nerve fiber length (CNFL) (mm/mm2)

The CCMetrics and ACCMetrics are offered free of charge under the license agreement for research purposes. 

If you publish results using CCMetrics/ACCMetrics, please mention the software in the methods section of your paper and acknowledgement of the group is always appreciated. We have listed below our papers on design and validation of the CCMetrics and ACCMetrics should you wish to cite them in your paper:

Normative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set. Tavakoli M et al. Diabetes Care. 2015; 38: 838-43.

Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal microscopy. Petropoulos IN, et al. Invest Ophthalmol Vis Sci. 2014; 55: 2071-8.

Small nerve fiber quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fiber density. Chen X et al. A. Diabetes Care. 2015; 38: 1138-44.

Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy. Alam U, et al. PLoS One. 2017 Jul 18;12(7).

Click on the link below for:

Access to license agreement for CCMetrics (manual tracing of nerve fibers)

Access to license agreement for ACCMetrics (automated tracing of nerve fibers)

Device compatibility: Heidelberg Retina Tomograph 3 with the Rostock Cornea Module (Heidelberg Engineering GmbH).

Operating System:Windows 32 & 64 bit and iMac – Apple with virtual box.

If you have any queries please email us at