research-v2

Publications

Review on CCM

Corneal confocal microscopy: ready for prime time. Petropoulos IN, Ponirakis G, Khan A, Gad H, Almuhannadi H, Brines M, Cerami A, Malik RA. Clin Exp Optom. 2019 Mar 4. doi: 10.1111/cxo.12887. Review.

Normative values for CCM

Normative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set. Tavakoli M, Ferdousi M, Petropoulos IN, Morris J, Pritchard N, Zhivov A, Ziegler D, Pacaud D, Romanchuk K, Perkins BA, Lovblom LE, Bril V, Singleton JR, Smith G, Boulton AJ, Efron N, Malik RA. Diabetes Care. 2015 May;38(5):838-43. doi: 10.2337/dc14-2311. Epub 2015 Jan 29.

Recommendation of CCM as a biomarker for diabetic peripheral neuropathy in clinical trials by the American Diabetes Association

Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetes Care. 2017 Jan;40(1):136-154. doi: 10.2337/dc16-2042. Review. No abstract available. 

Validation of CCM reproducibility

Repeatability of in vivo corneal confocal microscopy to quantify corneal nerve morphology. Petropoulos IN, Manzoor T, Morgan P, Fadavi H, Asghar O, Alam U, Ponirakis G, Dabbah MA, Chen X, Graham J, Tavakoli M, Malik RA. Cornea. 2013 May;32(5): e83-9. doi: 10.1097/ICO.0b013e3182749419.

Corneal confocal microscopy is a rapid reproducible ophthalmic technique for quantifying corneal nerve abnormalities. Kalteniece A, Ferdousi M, Adam S, Schofield J, Azmi S, Petropoulos I, Soran H, Malik RA. PLoS One. 2017 Aug 17;12(8): e0183040. doi: 10.1371/journal.pone.0183040. eCollection 2017.

Diagnostic performance of CCM

Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Tavakoli M, Quattrini C, Abbott C, Kallinikos P, Marshall A, Finnigan J, Morgan P, Efron N, Boulton AJ, Malik RA. Diabetes Care. 2010 Aug;33(8):1792-7. doi: 10.2337/dc10-0253. Epub 2010 Apr 30.

Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal microscopy. Petropoulos IN, Alam U, Fadavi H, Marshall A, Asghar O, Dabbah MA, Chen X, Graham J, Ponirakis G, Boulton AJ, Tavakoli M, Malik RA. Invest Ophthalmol Vis Sci. 2014 Apr 3;55(4):2071-8. doi: 10.1167/iovs.13-13787.

Small nerve fiber quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fiber density. Chen X, Graham J, Dabbah MA, Petropoulos IN, Ponirakis G, Asghar O, Alam U, Marshall A, Fadavi H, Ferdousi M, Azmi S, Tavakoli M, Efron N, Jeziorska M, Malik RA. Diabetes Care. 2015 Jun;38(6):1138-44. doi: 10.2337/dc14-2422. Epub 2015 Mar 20.

Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy. Alam U, Jeziorska M, Petropoulos IN, Asghar O, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Boulton AJM, Efron N, Malik RA. PLoS One. 2017 Jul 18;12(7): e0180175. doi: 10.1371/journal.pone.0180175. eCollection 2017.

Publications listed in chronological order:

2019

Early corneal nerve fibre damage and increased Langerhans cell density in children with type 1 diabetes mellitus. Ferdousi M, Romanchuk K, Mah JK, Virtanen H, Millar C, Malik RA, Pacaud D. Sci Rep. 2019 Jun 19;9(1):8758. doi: 10.1038/s41598-019-45116-z.

Early nerve fibre regeneration in individuals with type 1 diabetes after simultaneous pancreas and kidney transplantation. Azmi S, Jeziorska M, Ferdousi M, Petropoulos IN, Ponirakis G, Marshall A, Alam U, Asghar O, Atkinson A, Jones W, Boulton AJM, Brines M, Augustine T, Malik RA. Diabetologia. 2019 Aug;62(8):1478-1487. doi: 10.1007/s00125-019-4897-y. Epub 2019 Jun 7.

Correction: Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke. Gad H, Khan A, Akhtar N, Kamran S, El-Sotouhy A, Dargham SR, Petropoulos IN, Ponirakis G, Shuaib A, Streletz LJ, Malik RA. PLoS One. 2019 May 28;14(5): e0217672. doi: 10.1371/journal.pone.0217672. eCollection 2019.

A gain-of-function sodium channel β2-subunit mutation in painful diabetic neuropathy. Alsaloum M, Estacion M, Almomani R, Gerrits MM, Bönhof GJ, Ziegler D, Malik R, Ferdousi M, Lauria G, Merkies IS, Faber CG, Dib-Hajj S, Waxman SG; Propane Study Group. Mol Pain. 2019 Jan-Dec;15:1744806919849802. doi: 10.1177/1744806919849802.

Association of corneal nerve fiber measures with cognitive function in dementia.Ponirakis G, Al Hamad H, Sankaranarayanan A, Khan A, Chandran M, Ramadan M, Tosino R, Gawhale PV, Alobaidi M, AlSulaiti E, Elsotouhy A, Elorrabi M, Khan S, Nadukkandiyil N, Osman S, Thodi N, Almuhannadi H, Gad H, Mahfoud ZR, Al-Shibani F, Petropoulos IN, Own A, et al. Ann Clin Transl Neurol. 2019 Mar 2;6(4):689-697. doi: 10.1002/acn3.746. eCollection 2019 Apr.

Corneal Confocal Microscopy Detects Small-Fiber Neuropathy in Burning Mouth Syndrome: A Cross-Sectional Study.    O'Neill F, Marshall A, Ferdousi M, Malik RA. J Oral Facial Pain Headache. 2019 Summer;33(3):337–341. doi: 10.11607/ofph.2338. Epub 2019 Apr 24.

Bariatric surgery as a model to explore the basis and consequences of the Reaven hypothesis: Small, dense low-density lipoprotein and interleukin-6.  Adam S, Liu Y, Siahmansur T, Ho JH, Dhage SS, Yadav R, New JP, Donn R, Ammori BJ, Syed AA, Malik RA, Soran H, Durrington PN. Diab Vasc Dis Res. 2019 Mar;16(2):144-152. doi: 10.1177/1479164119826479.

Hypertension Contributes to Neuropathy in Patients With Type 1 Diabetes. Ponirakis G, Petropoulos IN, Alam U, Ferdousi M, Asghar O, Marshall A, Azmi S, Jeziorska M, Mahfoud ZR, Boulton AJM, Efron N, Nukada H, Malik RA.   Am J Hypertens. 2019 Jul 17;32(8):796-803. doi: 10.1093/ajh/hpz058.

Implementation of a Quality Index for Improvement of Quantification of Corneal Nerves in Corneal Confocal Microcopy Images: A Multicenter Study. Sturm D, Vollert J, Greiner T, Rice ASC, Kemp H, Treede RD, Schuh-Hofer S, Nielsen SE, Eitner L, Tegenthoff M, Petropoulos IN, Malik RA, Maier C, Schmidt-Wilcke T, Schargus M. Cornea. 2019 Jul;38(7):921-926. doi: 10.1097/ICO.0000000000001949.

Differential effects of gender and patient background diversity on the changes in metabolic and biophysical profiles in people with type-2 diabetes from different ethnicities who fast during Ramadan (H1439); a prospective study from Qatar. Dabbous Z, Bashir M, Elzouki AN, Ahmed MS, Farouk S, Hassanien M, Malik RA, Abou Samra AB, Elhadd T; PROFAST Study Group. Diabetes Res Clin Pract. 2019 Jun;152:171-176. doi: 10.1016/j.diabres.2019.03.032. Epub 2019 Mar 28.

Incidence of hypoglycaemia in patients with type-2 diabetes taking multiple glucose lowering therapies during Ramadan: the PROFAST Ramadan Study. Elhadd T, Dabbous Z, Bashir M, Elzouki A, Ghadban W, Baagar K, Benjamin S, Hassanien M, Saeed AAM, Dukhan K, Malik RA, Abou-Samra AB; PROFAST Study Group.. J Diabetes Metab Disord. 2018 Nov 19;17(2):309-314. doi: 10.1007/s40200-018-0374-2. eCollection 2018 Dec.

Diabetic muscle infarction: often misdiagnosed and mismanaged. Verjee MA, Abdelsamad NA, Qureshi S, Malik RA. Diabetes Metab Syndr Obes. 2019 Mar 5;12:285-290. doi: 10.2147/DMSO.S185839. eCollection 2019.

Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke. Gad H, Khan A, Akhtar N, Kamran S, El-Sotouhy A, Dargham SR, Petropoulos IN, Ponirakis G, Shuaib A, Streletz LJ, Malik RA. PLoS One. 2019 Mar 15;14(3):e0213319. doi: 10.1371/journal.pone.0213319. eCollection 2019. Erratum in: PLoS One. 2019 May 28;14(5):e0217672. 

Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar. Ponirakis G, Elhadd T, Chinnaiyan S, Dabbous Z, Siddiqui M, Al-Muhannadi H, Petropoulos I, Khan A, Ashawesh KA, Dukhan KM, Mahfoud ZR, Murgatroyd C, Slevin M, Malik RA. J Diabetes Investig. 2019 Mar 12. doi: 10.1111/jdi.13037. [Epub ahead of print]

Increased Intraepidermal Nerve Fiber Degeneration and Impaired Regeneration Relate to Symptoms and Deficits in Parkinson's Disease. Jeziorska M, Atkinson A, Kass-Iliyya L, Javed S, Kobylecki C, Gosal D, Marshall A, Silverdale M, Malik RA. Front Neurol. 2019 Feb 14;10:111. doi: 10.3389/fneur.2019.00111. eCollection 2019.

Corneal confocal microscopy: ready for prime time. Petropoulos IN, Ponirakis G, Khan A, Gad H, Almuhannadi H, Brines M, Cerami A, Malik RA. Clin Exp Optom. 2019 Mar 4. doi: 10.1111/cxo.12887. Review.

An update on the diagnosis and treatment of diabetic somatic and autonomic neuropathy. Azmi S, Petropoulos IN, Ferdousi M, Ponirakis G, Alam U, Malik RA. F1000Res. 2019 Feb 15;8. pii: F1000 Faculty Rev-186. doi: 10.12688/f1000research.17118.1. eCollection 2019. Review.

Continuous subcutaneous insulin infusion versus multiple daily insulin injections in patients with Type 1 diabetes mellitus who fast during Ramadan: A systematic review and meta-analysis. Gad H, Al-Muhannadi H, Mussleman P, Malik RA. Diabetes Res Clin Pract. 2019 May;151:265-274. doi: 10.1016/j.diabres.2019.02.019. Epub 2019 Feb 27. Review.

Longitudinal Changes in Corneal Cell and Nerve Fiber Morphology in Young Patients with Type 1 Diabetes with and without Diabetic Retinopathy: A 2-Year Follow-up Study. Deák EA, Szalai E, Tóth N, Malik RA, Berta A, Csutak A. Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):830-837. doi: 10.1167/iovs.18-24516.

Incidence, clinical features and outcomes of atrial fibrillation and stroke in Qatar. Imam YZ, Kamran S, Akhtar N, Deleu D, Singh R, Malik RA, Abdelmoneim MS, Bermejo P, Bourke P, Morgan D, Santos M, Joseph S, Shuaib A. Int J Stroke. 2019 Feb 21:1747493019830577. doi: 10.1177/1747493019830577. [Epub ahead of print]

Diagnosing and managing diabetic somatic and autonomic neuropathy.    Azmi S, Ferdousi M, Kalteniece A, Al-Muhannadi H, Al-Mohamedi A, Hadid NH, Mahmoud S, Bhat HA, Gad HYA, Khan A, Ponirakis G, Petropoulos IN, Alam U, Malik RA. Ther Adv Endocrinol Metab. 2019 Feb 4;10:2042018819826890. doi: 10.1177/2042018819826890. eCollection 2019. Review.

Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts.       Pasquier J, Spurgeon M, Bradic M, Thomas B, Robay A, Chidiac O, Dib MJ, Turjoman R, Liberska A, Staudt M, Fakhro KA, Menzies R, Jayyousi A, Zirie M, Suwaidi JA, Malik RA, Talal T, Rafii A, Mezey J, Rodriguez-Flores J, Crystal RG, Abi Khalil C.   Epigenomics. 2019 Feb;11(3):281-296. doi: 10.2217/epi-2018-0144. Epub 2018 Nov 1.

Diabetic Neuropathy: New Insights to Early Diagnosis and Treatments. Yorek M, Malik RA, Calcutt NA, Vinik A, Yagihashi S.      J Diabetes Res. 2018 Dec 10;2018:5378439. doi: 10.1155/2018/5378439. eCollection 2018. No abstract available. 

Pregabalin in the Management of Painful Diabetic Neuropathy: A Narrative Review. Azmi S, ElHadd KT, Nelson A, Chapman A, Bowling FL, Perumbalath A, Lim J, Marshall A, Malik RA, Alam U. Diabetes Ther. 2019 Feb;10(1):35-56. doi: 10.1007/s13300-018-0550-x. Epub 2018 Dec 18. Review.

The Impact of Diabetes on Outcomes After Acute Ischemic Stroke: A Prospective Observational Study. Akhtar N, Kamran S, Singh R, Malik RA, Deleu D, Bourke PJ, Joseph S, Santos MD, Morgan DM, Wadiwala FM, Francis R, Babu BM, George P, Ibrahim R, Garcia-Bermejo P, Shuaib A. J Stroke Cerebrovasc Dis. 2019 Mar;28(3):619-626. doi: 10.1016/j.jstrokecerebrovasdis.2018.11.003. Epub 2018 Dec 10.

2018

No Relation Between the Severity of Corneal Nerve, Epithelial, and Keratocyte Cell Morphology with Measures of Dry Eye Disease in Type 1 Diabetes.         Ferdousi M, Petropoulos IN, Kalteniece A, Azmi S, Ponirakis G, Efron N, Soran H, Malik RA.          Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5525-5530. doi: 10.1167/iovs.18-25321.

Corneal Confocal Microscopy detects a Reduction in Corneal Endothelial Cells and Nerve Fibres in Patients with Acute Ischemic Stroke. Khan A, Kamran S, Akhtar N, Ponirakis G, Al-Muhannadi H, Petropoulos IN, Al-Fahdawi S, Qahwaji R, Sartaj F, Babu B, Wadiwala MF, Shuaib A, Malik RA. Sci Rep. 2018 Nov 26;8(1):17333. doi: 10.1038/s41598-018-35298-3.

A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: Implications for a new paradigm in fibromyalgia etiopathogenesis. Grayston R, Czanner G, Elhadd K, Goebel A, Frank B, Üçeyler N, Malik RA, Alam U. Semin Arthritis Rheum. 2019 Apr;48(5):933-940. doi: 10.1016/j.semarthrit.2018.08.003. Epub 2018 Aug 23.

Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes: ADDITION-Denmark. Andersen ST, Grosen K, Tankisi H, Charles M, Andersen NT, Andersen H, Petropoulos IN, Malik RA, Jensen TS, Karlsson P. J Diabetes Complications. 2018 Dec;32(12):1153-1159. doi: 10.1016/j.jdiacomp.2018.09.016. Epub 2018 Oct 1.

Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia.  Pagovich OE, Vo ML, Zhao ZZ, Petropoulos IN, Yuan M, Lertsuwanroj B, Ciralsky J, Lai E, Kiss S, D'Amico DJ, Mezey JG, Malik RA, Crystal RG. Ann Neurol. 2018 Dec;84(6):893-904. doi: 10.1002/ana.25355.

Mirogabalin and emerging therapies for diabetic neuropathy. Javed S, Alam U, Malik RA. J Pain Res. 2018 Aug 22;11:1559-1566. doi: 10.2147/JPR.S145999. eCollection 2018. Review.

Diagnosing Diabetic Neuropathy: Something Old, Something New. Petropoulos IN, Ponirakis G, Khan A, Almuhannadi H, Gad H, Malik RA. Diabetes Metab J. 2018 Aug;42(4):255-269. doi: 10.4093/dmj.2018.0056. Review.

Corneal confocal microscopy detects corneal nerve damage and increased dendritic cells in Fabry disease.        Bitirgen G, Turkmen K, Malik RA, Ozkagnici A, Zengin N.Sci Rep. 2018 Aug 16;8(1):12244. doi: 10.1038/s41598-018-30688-z.

Corneal Nerve Migration Rate in a Healthy Control Population. Al Rashah K, Pritchard N, Dehghani C, Ruggeri A, Guimaraes P, Russell A, Malik RA, Efron N, Edwards K. Optom Vis Sci. 2018 Aug;95(8):672-677. doi: 10.1097/OPX.0000000000001254.

Keratocyte Density Is Reduced and Related to Corneal Nerve Damage in Diabetic Neuropathy. Kalteniece A, Ferdousi M, Azmi S, Marshall A, Soran H, Malik RA.    Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3584-3590. doi: 10.1167/iovs.18-23889.

Explanations for less small fibre neuropathy in South Asian versus European subjects with type 2 diabetes in the UK. Fadavi H, Tavakoli M, Foden P, Ferdousi M, Petropoulos IN, Jeziorska M, Chaturvedi N, Boulton AJM, Malik RA, Abbott CA. Diabetes Metab Res Rev. 2018 Oct;34(7):e3044. doi: 10.1002/dmrr.3044. Epub 2018 Aug 9.

Metformin Use Is Not Associated With B(12) Deficiency or Neuropathy in Patients with Type 2 Diabetes Mellitus in Qatar. Elhadd T, Ponirakis G, Dabbous Z, Siddique M, Chinnaiyan S, Malik RA. Front Endocrinol (Lausanne). 2018 May 25;9:248. doi: 10.3389/fendo.2018.00248. eCollection 2018.

Differentially expressed circulating microRNAs in the development of acute diabetic Charcot foot. Pasquier J, Ramachandran V, Abu-Qaoud MR, Thomas B, Benurwar MJ, Chidiac O, Hoarau-Véchot J, Robay A, Fakhro K, Menzies RA, Jayyousi A, Zirie M, Al Suwaidi J, Malik RA, Talal TK, Najafi-Shoushtari SH, Rafii A, Abi Khalil C. Epigenomics. 2018 Oct;10(10):1267-1278. doi: 10.2217/epi-2018-0052. Epub 2018 Jun 5.

Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: a pooled multinational consortium study.    Perkins BA, Lovblom LE, Bril V, Scarr D, Ostrovski I, Orszag A, Edwards K, Pritchard N, Russell A, Dehghani C, Pacaud D, Romanchuk K, Mah JK, Jeziorska M, Marshall A, Shtein RM, Pop-Busui R, Lentz SI, Boulton AJM, Tavakoli M, Efron N, Malik RA. Diabetologia. 2018 Aug;61(8):1856-1861. doi: 10.1007/s00125-018-4653-8. Epub 2018 Jun 4.

The Investigation and Treatment of Diabetic Gastroparesis. Kumar M, Chapman A, Javed S, Alam U, Malik RA, Azmi S. Clin Ther. 2018 Jun;40(6):850-861. doi: 10.1016/j.clinthera.2018.04.012. Epub 2018 May 7. Review.

A fully automated cell segmentation and morphometric parameter system for quantifying corneal endothelial cell morphology. Al-Fahdawi S, Qahwaji R, Al-Waisy AS, Ipson S, Ferdousi M, Malik RA, Brahma A. Comput Methods Programs Biomed. 2018 Jul;160:11-23. doi: 10.1016/j.cmpb.2018.03.015. Epub 2018 Mar 22.

Risk Factors for Failure of Direct Current Cardioversion in Patients with Type 2 Diabetes Mellitus and Atrial Fibrillation. Soran H, Banerjee M, Mohamad JB, Adam S, Ho JH, Ismaeel SM, Dhage S, Syed AA, Abdulla IMA, Younis N, Malik RA. Biomed Res Int. 2018 Mar 12;2018:5936180. doi: 10.1155/2018/5936180. eCollection 2018.

Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy. Iqbal Z, Azmi S, Yadav R, Ferdousi M, Kumar M, Cuthbertson DJ, Lim J, Malik RA, Alam U.         Clin Ther. 2018 Jun;40(6):828-849. doi: 10.1016/j.clinthera.2018.04.001. Epub 2018 Apr 30. Review.

In Vivo Confocal Microscopic Evaluation of Corneal Nerve Fibers and Dendritic Cells in Patients with Behçet's Disease. Bitirgen G, Tinkir Kayitmazbatir E, Satirtav G, Malik RA, Ozkagnici A. Front Neurol. 2018 Mar 28;9:204. doi: 10.3389/fneur.2018.00204. eCollection 2018.

Corneal nerve fiber size adds utility to the diagnosis and assessment of therapeutic response in patients with small fiber neuropathy. Brines M, Culver DA, Ferdousi M, Tannemaat MR, van Velzen M, Dahan A, Malik RA. Sci Rep. 2018 Mar 16;8(1):4734. doi: 10.1038/s41598-018-23107-w.

The influence of age, anthropometric and metabolic variables on LDIFLARE and corneal confocal microscopy in healthy individuals. Sharma S, Tobin V, Vas PRJ, Malik RA, Rayman G. PLoS One. 2018 Mar 8;13(3):e0193452. doi: 10.1371/journal.pone.0193452. eCollection 2018.

Peripheral neuropathy in patients with multiple sclerosis.   Khan A, Kamran S, Ponirakis G, Akhtar N, Khan R, George P, Babu BM, Ibrahim FM, Petropoulos IN, Canibano BG, Wilins SS, Deleu D, Shuaib A, Malik RA.        PLoS One. 2018 Mar 7;13(3):e0193270. doi: 10.1371/journal.pone.0193270. eCollection 2018.

Factors that Can Help Select the Timing for Decompressive Hemicraniectomy for Malignant MCA Stroke.           Kamran S, Salam A, Akhtar N, Alboudi A, Kamran K, Singh R, Amir N, Inshasi J, Qidwai U, Malik RA, Shuaib A. Transl Stroke Res. 2018 Dec;9(6):600-607. doi: 10.1007/s12975-018-0616-0. Epub 2018 Mar 6.

Corneal Nerve Fractal Dimension: A Novel Corneal Nerve Metric for the Diagnosis of Diabetic Sensorimotor Polyneuropathy.   Chen X, Graham J, Petropoulos IN, Ponirakis G, Asghar O, Alam U, Marshall A, Ferdousi M, Azmi S, Efron N, Malik RA. Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):1113-1118. doi: 10.1167/iovs.17-23342.

Greater corneal nerve loss at the inferior whorl is related to the presence of diabetic neuropathy and painful diabetic neuropathy.     Kalteniece A, Ferdousi M, Petropoulos I, Azmi S, Adam S, Fadavi H, Marshall A, Boulton AJM, Efron N, Faber CG, Lauria G, Soran H, Malik RA. Sci Rep. 2018 Feb 19;8(1):3283. doi: 10.1038/s41598-018-21643-z.

2017

Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation.            Alam U, Fawwad A, Shaheen F, Tahir B, Basit A, Malik RA. J Diabetes Res. 2017;2017:7928083. doi: 10.1155/2017/7928083. Epub 2017 Dec 28.

Corneal confocal microscopy detects severe small fiber neuropathy in diabetic patients with Charcot neuroarthropathy. Khan A, Petropoulos IN, Ponirakis G, Menzies RA, Chidiac O, Pasquier J, Abi Khalil C, Talal TK, Malik RA. J Diabetes Investig. 2018 Sep;9(5):1167-1172. doi: 10.1111/jdi.12806. Epub 2018 Feb 26.

Hypercholesterolaemia - practical information for non-specialists. Soran H, Adam S, Mohammad JB, Ho JH, Schofield JD, Kwok S, Siahmansur T, Liu Y, Syed AA, Dhage SS, Stefanutti C, Donn R, Malik RA, Banach M, Durrington PN. Arch Med Sci. 2018 Jan;14(1):1-21. doi: 10.5114/aoms.2018.72238. Epub 2017 Dec 19.

Diabetic neuropathy and painful diabetic neuropathy: Cinderella complications in South East Asia. Almuhannadi H, Ponirakis G, Khan A, Malik RA. J Pak Med Assoc. 2018 Jan;68(1):85-89.

The H-Reflex as a Biomarker for Spinal Disinhibition in Painful Diabetic Neuropathy. Lee-Kubli C, Marshall AG, Malik RA, Calcutt NA. Curr Diab Rep. 2018 Jan 23;18(1):1. doi: 10.1007/s11892-018-0969-5. Review.

Corneal and Retinal Neuronal Degeneration in Early Stages of Diabetic Retinopathy. Srinivasan S, Dehghani C, Pritchard N, Edwards K, Russell AW, Malik RA, Efron N. Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6365-6373. doi: 10.1167/iovs.17-22736.

Effect of Roux-en-Y Bariatric Surgery on Lipoproteins, Insulin Resistance, and Systemic and Vascular Inflammation in Obesity and Diabetes.            Yadav R, Hama S, Liu Y, Siahmansur T, Schofield J, Syed AA, France M, Pemberton P, Adam S, Ho JH, Aghamohammadzadeh R, Dhage S, Donn R, Malik RA, New JP, Jeziorska M, Durrington P, Ammori BA, Soran H. Front Immunol. 2017 Nov 15;8:1512. doi: 10.3389/fimmu.2017.01512. eCollection 2017.

Circulating microparticles in acute diabetic Charcot foot exhibit a high content of inflammatory cytokines, and support monocyte-to-osteoclast cell induction. Pasquier J, Thomas B, Hoarau-Véchot J, Odeh T, Robay A, Chidiac O, Dargham SR, Turjoman R, Halama A, Fakhro K, Menzies R, Jayyousi A, Zirie M, Al Suwaidi J, Rafii A, Malik RA, Talal T, Abi Khalil C. Sci Rep. 2017 Nov 27;7(1):16450. doi: 10.1038/s41598-017-16365-7.

Ophthalmic and clinical factors that predict four-year development and worsening of diabetic retinopathy in type 1 diabetes.  Srinivasan S, Dehghani C, Pritchard N, Edwards K, Russell AW, Malik RA, Efron N. J Diabetes Complications. 2018 Jan;32(1):67-74. doi: 10.1016/j.jdiacomp.2017.09.002. Epub 2017 Sep 14.

Effects of procalcitonin-guided treatment on antibiotic use and need for mechanical ventilation in patients with acute asthma exacerbation: Meta-analysis of randomized controlled trials. Ibrahim WH, Mushtaq K, Raza T, Kartha A, Saleh AO, Malik RA. Int J Infect Dis. 2017 Dec;65:75-80. doi: 10.1016/j.ijid.2017.10.005. Epub 2017 Oct 14.

Corneal Confocal Microscopy Detects Corneal Nerve Damage in Patients Admitted With Acute Ischemic Stroke. Khan A, Akhtar N, Kamran S, Ponirakis G, Petropoulos IN, Tunio NA, Dargham SR, Imam Y, Sartaj F, Parray A, Bourke P, Khan R, Santos M, Joseph S, Shuaib A, Malik RA. Stroke. 2017 Nov;48(11):3012-3018. doi: 10.1161/STROKEAHA.117.018289. Epub 2017 Oct 10.

CIDP and other inflammatory neuropathies in diabetes - diagnosis and management. Rajabally YA, Stettner M, Kieseier BC, Hartung HP, Malik RA. Nat Rev Neurol. 2017 Oct;13(10):599-611. doi: 10.1038/nrneurol.2017.123. Epub 2017 Sep 15. Review.

Diabetic Neuropathy and Gait: A Review. Alam U, Riley DR, Jugdey RS, Azmi S, Rajbhandari S, D'Août K, Malik RA. Diabetes Ther. 2017 Dec;8(6):1253-1264. doi: 10.1007/s13300-017-0295-y. Epub 2017 Sep 1. Review.

Presence of Peripheral Neuropathy Is Associated With Progressive Thinning of Retinal Nerve Fiber Layer in Type 1 Diabetes. Dehghani C, Srinivasan S, Edwards K, Pritchard N, Russell AW, Malik RA, Efron N. Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO234-BIO239. doi: 10.1167/iovs.17-21801.

Longitudinal study of neuropathy, microangiopathy, and autophagy in sural nerve: Implications for diabetic neuropathy. Mohseni S, Badii M, Kylhammar A, Thomsen NOB, Eriksson KF, Malik RA, Rosén I, Dahlin LB. Brain Behav. 2017 Jul 12;7(8): e00763. doi: 10.1002/brb3.763. eCollection 2017 Aug.

Corneal confocal microscopy is a rapid reproducible ophthalmic technique for quantifying corneal nerve abnormalities. Kalteniece A, Ferdousi M, Adam S, Schofield J, Azmi S, Petropoulos I, Soran H, Malik RA. PLoS One. 2017 Aug 17;12(8): e0183040. doi: 10.1371/journal.pone.0183040. eCollection 2017.

Corneal Confocal Microscopy: An Imaging Endpoint for Axonal Degeneration in Multiple Sclerosis. Petropoulos IN, Kamran S, Li Y, Khan A, Ponirakis G, Akhtar N, Deleu D, Shuaib A, Malik RA. Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3677-3681. doi: 10.1167/iovs.17-22050.

Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy. Alam U, Jeziorska M, Petropoulos IN, Asghar O, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Boulton AJM, Efron N, Malik RA. PLoS One. 2017 Jul 18;12(7): e0180175. doi: 10.1371/journal.pone.0180175. eCollection 2017.

Optical coherence tomography predicts 4-year incident diabetic neuropathy. Srinivasan S, Dehghani C, Pritchard N, Edwards K, Russell AW, Malik RA, Efron N. Ophthalmic Physiol Opt. 2017 Jul;37(4):451-459. doi: 10.1111/opo.12391.

Use of Corneal Confocal Microscopy to Evaluate Small Nerve Fibers in Patients with Human Immunodeficiency Virus. Kemp HI, Petropoulos IN, Rice ASC, Vollert J, Maier C, Strum D, Schargus M, Peto T, Hau S, Chopra R, Malik RA.   JAMA Ophthalmol. 2017 Jul 1;135(7):795-800. doi: 10.1001/jamaophthalmol.2017.1703. Erratum in: JAMA Ophthalmol. 2017 Sep 1;135(9):1006. 

Use of Corneal Confocal Microscopy to Detect Corneal Nerve Loss and Increased Dendritic Cells in Patients With Multiple Sclerosis. Bitirgen G, Akpinar Z, Malik RA, Ozkagnici A. JAMA Ophthalmol. 2017 Jul 1;135(7):777-782. doi: 10.1001/jamaophthalmol.2017.1590.

Corneal confocal microscopy best identifies the development and progression of neuropathy in patients with type 1 diabetes. Edwards K, Pritchard N, Dehghani C, Vagenas D, Russell A, Malik RA, Efron N. J Diabetes Complications. 2017 Aug;31(8):1325-1327. doi: 10.1016/j.jdiacomp.2017.04.025. Epub 2017 May 5.

Perceptions of Painful Diabetic Peripheral Neuropathy in South-East Asia: Results from Patient and Physician Surveys. Malik RA, Aldinc E, Chan SP, Deerochanawong C, Hwu CM, Rosales RL, Yeung CY, Fujii K, Parsons B. Adv Ther. 2017 Jun;34(6):1426-1437. doi: 10.1007/s12325-017-0536-5. Epub 2017 May 13.

Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain.            Culver DA, Dahan A, Bajorunas D, Jeziorska M, van Velzen M, Aarts LPHJ, Tavee J, Tannemaat MR, Dunne AN, Kirk RI, Petropoulos IN, Cerami A, Malik RA, Brines M. Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO52-BIO60. doi: 10.1167/iovs.16-21291.

Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome.  Khavandi K, Aghamohammadzadeh R, Luckie M, Brownrigg J, Alam U, Khattar R, Malik RA, Heagerty AM, Greenstein AS. J Am Heart Assoc. 2017 Apr 11;6(4). pii: e004603. doi: 10.1161/JAHA.116.004603.

Small-fibre neuropathy in men with type 1 diabetes and erectile dysfunction: a cross-sectional study. Azmi S, Ferdousi M, Alam U, Petropoulos IN, Ponirakis G, Marshall A, Asghar O, Fadavi H, Jones W, Tavakoli M, Boulton AJM, Jeziorska M, Soran H, Efron N, Malik RA. Diabetologia. 2017 Jun;60(6):1094-1101. doi: 10.1007/s00125-017-4245-z. Epub 2017 Mar 29.

Network topology of NaV1.7 mutations in sodium channel-related painful disorders. Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, Merkies IS, Dib-Hajj SD, Mantegazza M, Waxman SG, Lauria G; PROPANE Study Group. BMC Syst Biol. 2017 Feb 24;11(1):28. doi: 10.1186/s12918-016-0382-0.

Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. Marshall AG, Lee-Kubli C, Azmi S, Zhang M, Ferdousi M, Mixcoatl-Zecuatl T, Petropoulos IN, Ponirakis G, Fineman MS, Fadavi H, Frizzi K, Tavakoli M, Jeziorska M, Jolivalt CG, Boulton AJM, Efron N, Calcutt NA, Malik RA. Diabetes. 2017 May;66(5):1380-1390. doi: 10.2337/db16-1181. Epub 2017 Feb 15.

Effects of panretinal laser photocoagulation on the corneal nerve plexus and retinal nerve fiber layer in retinal vein occlusion. Bitirgen G, Belviranli S, Malik RA, Kerimoglu H, Ozkagnici A. Eur J Ophthalmol. 2017 Aug 30;27(5):591-595. doi: 10.5301/ejo.5000910. Epub 2017 Jan 23.

Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin-evoked peripheral neuropathy. Areti A, Komirishetty P, Akuthota M, Malik RA, Kumar A. J Pineal Res. 2017 Apr;62(3). doi: 10.1111/jpi.12393. Epub 2017 Mar 1.

Assessment of Corneal Sensation, Innervation and Retinal Nerve Fiber Layer in Patients Treated with Multiple Intravitreal Ranibizumab Injections. Bitirgen G, Belviranli S, Malik RA, Kerimoglu H, Satirtav G, Zengin N. PLoS One. 2017 Jan 13;12(1):e0170271. doi: 10.1371/journal.pone.0170271. eCollection 2017.

COL6A5 variants in familial neuropathic chronic itch. Martinelli-Boneschi F, Colombi M, Castori M, Devigili G, Eleopra R, Malik RA, Ritelli M, Zoppi N, Dordoni C, Sorosina M, Grammatico P, Fadavi H, Gerrits MM, Almomani R, Faber CG, Merkies IS, Toniolo D; INGI Network., Cocca M, Doglioni C, Waxman SG, Dib-Hajj SD, et al.          Brain. 2017 Mar 1;140(3):555-567. doi: 10.1093/brain/aww343.

Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetes Care. 2017 Jan;40(1):136-154. doi: 10.2337/dc16-2042. Review. No abstract available. 

2016

NerveCheck for the Detection of Sensory Loss and Neuropathic Pain in Diabetes.  Ponirakis G, Odriozola MN, Odriozola S, Petropoulos IN, Azmi S, Ferdousi M, Fadavi H, Alam U, Marshall A, Jeziorska M, Miro A, Kheyami A, Tavakoli M, Al-Ahmar A, Odriozola MB, Odriozola A, Malik RA. Diabetes Technol Ther. 2016 Dec;18(12):800-805. Epub 2016 Dec 6.

Iodine-123 metaiodobenzylguanidine scintigraphy for the assessment of cardiac sympathetic innervation and the relationship with cardiac autonomic function in healthy adults using standardized methods. Asghar O, Arumugam P, Armstrong I, Ray S, Schmitt M, Malik RA. Nucl Med Commun. 2017 Jan;38(1):44-50.

The perception of affective touch in Parkinson's disease and its relation to small fibre neuropathy. Kass-Iliyya L, Leung M, Marshall A, Trotter P, Kobylecki C, Walker S, Gosal D, Jeziorska M, Malik RA, McGlone F, Silverdale MA. Eur J Neurosci. 2017 Jan;45(2):232-237. doi: 10.1111/ejn.13481. Epub 2016 Nov 28.

Focal loss volume of ganglion cell complex in diabetic neuropathy. Srinivasan S, Pritchard N, Sampson GP, Edwards K, Vagenas D, Russell AW, Malik RA, Efron N. Clin Exp Optom. 2016 Nov;99(6):526-534. doi: 10.1111/cxo.12379. Epub 2016 Mar 29.

Response to Comment on Almurdhi et al. Reduced Lower-Limb Muscle Strength and Volume in Patients With Type 2 Diabetes in Relation to Neuropathy, Intramuscular Fat, and Vitamin D Levels. Diabetes Care 2016;39:441-447.    Almurdhi MM, Reeves ND, Bowling FL, Boulton AJ, Jeziorska M, Malik RA. Diabetes Care. 2016 Oct;39(10):e184-5. doi: 10.2337/dci16-0020. No abstract available. 

Secondary Stroke Prevention: Improving Diagnosis and Management with Newer Technologies. Imam YZ, D'Souza A, Malik RA, Shuaib A. Transl Stroke Res. 2016 Dec;7(6):458-477. Epub 2016 Sep 2. Review.

A fully automatic nerve segmentation and morphometric parameter quantification system for early diagnosis of diabetic neuropathy in corneal images. Al-Fahdawi S, Qahwaji R, Al-Waisy AS, Ipson S, Malik RA, Brahma A, Chen X.        Comput Methods Programs Biomed. 2016 Oct;135:151-66. doi: 10.1016/j.cmpb.2016.07.032. Epub 2016 Jul 27.

Ethnic variation in acute cerebrovascular disease: Analysis from the Qatar stroke registry. Akhtar N, Salam A, Kamran S, Bourke P, Joseph S, Santos M, Khan R, Irfan F, Deleu D, Malik RA, Shuaib A. Eur Stroke J. 2016 Sep;1(3):231-241. doi: 10.1177/2396987316663776. Epub 2016 Aug 10.

Abnormal Anterior Corneal Morphology in Diabetes Observed Using In Vivo Laser-scanning Confocal Microscopy. Dehghani C, Pritchard N, Edwards K, Russell AW, Malik RA, Efron N. Ocul Surf. 2016 Oct;14(4):507-514. doi: 10.1016/j.jtos.2016.07.004. Epub 2016 Aug 20.

Subjects with Extreme-Duration Type 1 Diabetes Exhibit No Structural or Functional Abnormality on Cardiac MRI. Asghar O, Miller C, Ray S, Schmitt M, Malik RA. Diabetes Care. 2016 Oct;39(10):e167-8. doi: 10.2337/dc16-0760. Epub 2016 Aug 3. No abstract available. 

A rapid decline in corneal small fibers and occurrence of foot ulceration and Charcot foot. Dehghani C, Russell AW, Perkins BA, Malik RA, Pritchard N, Edwards K, Shahidi AM, Srinivasan S, Efron N. J Diabetes Complications. 2016 Nov - Dec;30(8):1437-1439. doi: 10.1016/j.jdiacomp.2016.07.004. Epub 2016 Jul 16.

Diagnostic capability of retinal thickness measures in diabetic peripheral neuropathy. Srinivasan S, Pritchard N, Sampson GP, Edwards K, Vagenas D, Russell AW, Malik RA, Efron N. J Optom. 2017 Oct - Dec;10(4):215-225. doi: 10.1016/j.optom.2016.05.003. Epub 2016 Jul 14.

Adhesive capsulitis of the shoulder and diabetes: a meta-analysis of prevalence.   Zreik NH, Malik RA, Charalambous CP. Muscles Ligaments Tendons J. 2016 May 19;6(1):26-34. doi: 10.11138/mltj/2016.6.1.026. eCollection 2016 Jan-Mar. Review.

Repeatability of Measuring Corneal Nerve Migration Rate in Individuals with and Without Diabetes. Al Rashah K, Pritchard N, Dehghani C, Ruggeri A, Guimaraes P, Poole C, Russell A, Malik R, Efron N, Edwards K. Cornea. 2016 Oct;35(10):1355-61. doi: 10.1097/ICO.0000000000000913.

An Automatic Tool for Quantification of Nerve Fibers in Corneal Confocal Microscopy Images. Chen X, Graham J, Dabbah MA, Petropoulos IN, Tavakoli M, Malik RA.IEEE Trans Biomed Eng. 2017 Apr;64(4):786-794. doi: 10.1109/TBME.2016.2573642. Epub 2016 Jun 7.

Diabetes Dyslipidemia.           Schofield JD, Liu Y, Rao-Balakrishna P, Malik RA, Soran H. Diabetes Ther. 2016 Jun;7(2):203-19. doi: 10.1007/s13300-016-0167-x. Epub 2016 Apr 7. Review.

Vitamin D for the treatment of painful diabetic neuropathy. Basit A, Basit KA, Fawwad A, Shaheen F, Fatima N, Petropoulos IN, Alam U, Malik RA. BMJ Open Diabetes Res Care. 2016 Feb 10;4(1):e000148. doi: 10.1136/bmjdrc-2015-000148. eCollection 2016.

Vitamin D and Diabetic Complications: True or False Prophet? Alam U, Arul-Devah V, Javed S, Malik RA. Diabetes Ther. 2016 Mar;7(1):11-26. doi: 10.1007/s13300-016-0159-x. Epub 2016 Mar 12. Review.

Early Corneal Cellular and Nerve Fiber Pathology in Young Patients With Type 1 Diabetes Mellitus Identified Using Corneal Confocal Microscopy.            Szalai E, Deák E, Módis L Jr, Németh G, Berta A, Nagy A, Felszeghy E, Káposzta R, Malik RA, Csutak A.         Invest Ophthalmol Vis Sci. 2016 Mar;57(3):853-8. doi: 10.1167/iovs.15-18735.

Development of a Novel Technique to Measure Corneal Nerve Migration Rate.     Edwards K, Pritchard N, Poole C, Dehghani C, Al Rashah K, Russell A, Malik RA, Efron N. Cornea. 2016 May;35(5):700-5. doi: 10.1097/ICO.0000000000000790.

Retinal Tissue Thickness is Reduced in Diabetic Peripheral Neuropathy. Srinivasan S, Pritchard N, Vagenas D, Edwards K, Sampson GP, Russell AW, Malik RA, Efron N. Curr Eye Res. 2016 Oct;41(10):1359-1366. Epub 2016 Feb 29.

2015

Corneal confocal microscopy in chronic inflammatory demyelinating polyneuropathy. Stettner M, Hinrichs L, Guthoff R, Bairov S, Petropoulos IN, Warnke C, Hartung HP, Malik RA, Kieseier BC. Ann Clin Transl Neurol. 2015 Dec 28;3(2):88-100. doi: 10.1002/acn3.275. eCollection 2016 Feb.

Vitamin D Deficiency Is Not Associated with Diabetic Retinopathy or Maculopathy. Alam U, Amjad Y, Chan AW, Asghar O, Petropoulos IN, Malik RA. J Diabetes Res. 2016;2016:6156217. doi: 10.1155/2016/6156217. Epub 2016 Jan 14.

Retinal tissue thickness in type 1 and type 2 diabetes. Srinivasan S, Pritchard N, Sampson GP, Edwards K, Vagenas D, Russell AW, Malik RA, Efron N. Clin Exp Optom. 2016 Jan;99(1):78-83. doi: 10.1111/cxo.12318.

Risk Factors Associated with Corneal Nerve Alteration in Type 1 Diabetes in the Absence of Neuropathy: A Longitudinal In Vivo Corneal Confocal Microscopy Study.      Dehghani C, Pritchard N, Edwards K, Russell AW, Malik RA, Efron N. Cornea. 2016 Jun;35(6):847-52. doi: 10.1097/ICO.0000000000000760.

Reduced Lower-Limb Muscle Strength and Volume in Patients With Type 2 Diabetes in Relation to Neuropathy, Intramuscular Fat, and Vitamin D Levels. Almurdhi MM, Reeves ND, Bowling FL, Boulton AJ, Jeziorska M, Malik RA. Diabetes Care. 2016 Mar;39(3):441-7. doi: 10.2337/dc15-0995. Epub 2016 Jan 6.

Retinal thickness profile of individuals with diabetes. Srinivasan S, Pritchard N, Sampson GP, Edwards K, Vagenas D, Russell AW, Malik RA, Efron N. Ophthalmic Physiol Opt. 2016 Mar;36(2):158-66. doi: 10.1111/opo.12263. Epub 2015 Dec 21.

Treating Diabetic Neuropathy: Present Strategies and Emerging Solutions. Javed S, Alam U, Malik RA. Rev Diabet Stud. 2015 Spring-Summer;12(1-2):63-83. doi: 10.1900/RDS.2015.12.63. Epub 2015 Aug 10. Review.

Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome. Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Køber LV, Lawson FC, Ping L, Wei X, Lewis EF, Maggioni AP, McMurray JJ, Probstfield JL, Riddle MC, Solomon SD, Tardif JC; ELIXA Investigators. N Engl J Med. 2015 Dec 3;373(23):2247-57. doi: 10.1056/NEJMoa1509225.

Small fiber neuropathy in Parkinson's disease: A clinical, pathological and corneal confocal microscopy study. Kass-Iliyya L, Javed S, Gosal D, Kobylecki C, Marshall A, Petropoulos IN, Ponirakis G, Tavakoli M, Ferdousi M, Chaudhuri KR, Jeziorska M, Malik RA, Silverdale MA. Parkinsonism Relat Disord. 2015 Dec;21(12):1454-60. doi: 10.1016/j.parkreldis.2015.10.019. Epub 2015 Nov 3.

Corneal Confocal Microscopy Detects Small Fibre Neuropathy in Patients with Upper Gastrointestinal Cancer and Nerve Regeneration in Chemotherapy Induced Peripheral Neuropathy.       Ferdousi M, Azmi S, Petropoulos IN, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Malik I, Mansoor W, Malik RA. PLoS One. 2015 Oct 2;10(10):e0139394. doi: 10.1371/journal.pone.0139394. eCollection 2015.

Erratum. Small fiber neuropathy in patients with latent autoimmune diabetes in adults. Diabetes Care 2015;38:e102-e103. Alam U, Asghar O, Petropoulos IN, Jeziorska M, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Boulton AJ, Efron N, Malik RA. Diabetes Care. 2015 Oct;38(10):1992. doi: 10.2337/dc15-er10a. No abstract available. 

Effect of Extended-Release Niacin on High-Density Lipoprotein (HDL) Functionality, Lipoprotein Metabolism, and Mediators of Vascular Inflammation in Statin-Treated Patients.       Yadav R, Liu Y, Kwok S, Hama S, France M, Eatough R, Pemberton P, Schofield J, Siahmansur TJ, Malik R, Ammori BA, Issa B, Younis N, Donn R, Stevens A, Durrington P, Soran H. J Am Heart Assoc. 2015 Sep 15;4(9):e001508. doi: 10.1161/JAHA.114.001508.

The Reliability and Reproducibility of Corneal Confocal Microscopy in Children. Pacaud D, Romanchuk KG, Tavakoli M, Gougeon C, Virtanen H, Ferdousi M, Nettel-Aguirre A, Mah JK, Malik RA. Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5636-40. doi: 10.1167/iovs.15-16995.

Diagnosis and management of type 1 diabetes in adults: summary of updated NICE guidance. Amiel SA, Pursey N, Higgins B, Dawoud D; Guideline Development Group. BMJ. 2015 Aug 26;351:h4188. doi: 10.1136/bmj.h4188. No abstract available. 

Comment on Sharma. Mitochondrial Hormesis and Diabetic Complications. Diabetes 2015;64:663-672. Kumar A, Yerra VG, Malik RA. Diabetes. 2015 Sep;64(9):e32-3; discussion e34. doi: 10.2337/db15-0589. No abstract available. 

Focused Tortuosity Definitions Based on Expert Clinical Assessment of Corneal Subbasal Nerves. Lagali N, Poletti E, Patel DV, McGhee CN, Hamrah P, Kheirkhah A, Tavakoli M, Petropoulos IN, Malik RA, Utheim TP, Zhivov A, Stachs O, Falke K, Peschel S, Guthoff R, Chao C, Golebiowski B, Stapleton F, Ruggeri A. Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5102-9. doi: 10.1167/iovs.15-17284.

Can corneal confocal microscopy help in early detection of neuronal damage and cognitive dysfunction as a consequence of metabolic syndrome in schizophrenia? Sankaranarayanan A, Malik RA. Early Interv Psychiatry. 2017 Jun;11(3):271-274. doi: 10.1111/eip.12258. Epub 2015 Jul 14. No abstract available. 

Small Fiber Neuropathy in Patients With Latent Autoimmune Diabetes in Adults.  Alam U, Asghar O, Petropoulos IN, Jeziorska M, Fadavi H, Ponirakis G, Marshall A, Tavakoli M, Boulton AJ, Efron N, Malik RA. Diabetes Care. 2015 Jul;38(7):e102-3. doi: 10.2337/dc14-2354. No abstract available.  Erratum in: Diabetes Care. 2015 Oct;38(10):1992.

In vivo corneal confocal microscopic analysis in patients with keratoconus.           Bitirgen G, Ozkagnici A, Bozkurt B, Malik RA.Int J Ophthalmol. 2015 Jun 18;8(3):534-9. doi: 10.3980/j.issn.2222-3959.2015.03.17. eCollection 2015.

Automated Quantification of Neuropad Improves Its Diagnostic Ability in Patients with Diabetic Neuropathy.    Ponirakis G, Fadavi H, Petropoulos IN, Azmi S, Ferdousi M, Dabbah MA, Kheyami A, Alam U, Asghar O, Marshall A, Tavakoli M, Al-Ahmar A, Javed S, Jeziorska M, Malik RA.          J Diabetes Res. 2015;2015:847854. doi: 10.1155/2015/847854. Epub 2015 May 12.

Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo. Bentley-Lewis R, Aguilar D, Riddle MC, Claggett B, Diaz R, Dickstein K, Gerstein HC, Johnston P, Lawson F, Lewis EF, Maggioni AP, McMurray JJ, Ping L, Probstfield JL, Solomon SD, Tardif JC, Wu Y, Pfeffer MA; ELIXA Investigators. Am Heart J. 2015 May;169(5):631-638.e7. doi: 10.1016/j.ahj.2015.02.002. Epub 2015 Feb 12.

Utility of Assessing Nerve Morphology in Central Cornea Versus Whorl Area for Diagnosing Diabetic Peripheral Neuropathy. Pritchard N, Dehghani C, Edwards K, Burgin E, Cheang N, Kim H, Mikhaiel M, Stanton G, Russell AW, Malik RA, Efron N. Cornea. 2015 Jul;34(7):756-61. doi: 10.1097/ICO.0000000000000447.

Corneal Confocal Microscopy Identifies Small-Fiber Neuropathy in Subjects with Impaired Glucose Tolerance Who Develop Type 2 Diabetes. Azmi S, Ferdousi M, Petropoulos IN, Ponirakis G, Alam U, Fadavi H, Asghar O, Marshall A, Atkinson AJ, Jones W, Boulton AJ, Tavakoli M, Jeziorska M, Malik RA. Diabetes Care. 2015 Aug;38(8):1502-8. doi: 10.2337/dc14-2733. Epub 2015 Apr 15.

Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria. Petropoulos IN, Green P, Chan AW, Alam U, Fadavi H, Marshall A, Asghar O, Efron N, Tavakoli M, Malik RA. PLoS One. 2015 Apr 8;10(4): e0123517. doi: 10.1371/journal.pone.0123517. eCollection 2015.

Small nerve fiber quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fiber density. Chen X, Graham J, Dabbah MA, Petropoulos IN, Ponirakis G, Asghar O, Alam U, Marshall A, Fadavi H, Ferdousi M, Azmi S, Tavakoli M, Efron N, Jeziorska M, Malik RA. Diabetes Care. 2015 Jun;38(6):1138-44. doi: 10.2337/dc14-2422. Epub 2015 Mar 20.

The Inferior Whorl for Detecting Diabetic Peripheral Neuropathy Using Corneal Confocal Microscopy. Petropoulos IN, Ferdousi M, Marshall A, Alam U, Ponirakis G, Azmi S, Fadavi H, Efron N, Tavakoli M, Malik RA. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2498-504. doi: 10.1167/iovs.14-15919.

Normative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set. Tavakoli M, Ferdousi M, Petropoulos IN, Morris J, Pritchard N, Zhivov A, Ziegler D, Pacaud D, Romanchuk K, Perkins BA, Lovblom LE, Bril V, Singleton JR, Smith G, Boulton AJ, Efron N, Malik RA. Diabetes Care. 2015 May;38(5):838-43. doi: 10.2337/dc14-2311. Epub 2015 Jan 29.

Response to comment on Malik. Which test for diagnosing early human diabetic neuropathy? Diabetes 2014; 63:2206-2208. Petropoulos IN, Tavakoli M, Marshall A, Malik RA.      Diabetes. 2015 Feb;64(2): e2-3. doi: 10.2337/db14-1608. No abstract available. 

Corneal confocal microscopy predicts 4-year incident peripheral neuropathy in type 1 diabetes. Pritchard N, Edwards K, Russell AW, Perkins BA, Malik RA, Efron N.      Diabetes Care. 2015 Apr;38(4):671-5. doi: 10.2337/dc14-2114. Epub 2015 Jan 8.

Corneal confocal microscopy for the diagnosis of diabetic autonomic neuropathy. Tavakoli M, Begum P, McLaughlin J, Malik RA. Muscle Nerve. 2015 Sep;52(3):363-70. doi: 10.1002/mus.24553. Epub 2015 Jun 18.

Treatment of painful diabetic neuropathy. Javed S, Petropoulos IN, Alam U, Malik RA. Ther Adv Chronic Dis. 2015 Jan;6(1):15-28. doi: 10.1177/2040622314552071. Review.

Medalists with extreme duration of type 1 diabetes exhibit only mild diastolic dysfunction and myocardial fibrosis.       Fagan A, Asghar O, Pearce K, Stout M, Ray SG, Schmitt M, Malik RA. Diabetes Care. 2015 Jan;38(1): e5-6. doi: 10.2337/dc14-2100. No abstract available. 

Corneal confocal microscopy shows an improvement in small-fiber neuropathy in subjects with type 1 diabetes on continuous subcutaneous insulin infusion compared with multiple daily injection. Azmi S, Ferdousi M, Petropoulos IN, Ponirakis G, Fadavi H, Tavakoli M, Alam U, Jones W, Marshall A, Jeziorska M, Boulton AJ, Efron N, Malik RA. Diabetes Care. 2015 Jan;38(1):e3-4. doi: 10.2337/dc14-1698. No abstract available. 

2014

Preface. Zochodne DW, Malik RA.      Handb Clin Neurol. 2014; 126:ix. doi: 10.1016/B978-0-444-53480-4.09989-6. No abstract available. 

General aspects of diabetes mellitus.Alam U, Asghar O, Azmi S, Malik RA.  Handb Clin Neurol. 2014; 126:211-22. doi: 10.1016/B978-0-444-53480-4.00015-1. Review.

Natural history of corneal nerve morphology in mild neuropathy associated with type 1 diabetes: development of a potential measure of diabetic peripheral neuropathy.          Dehghani C, Pritchard N, Edwards K, Vagenas D, Russell AW, Malik RA, Efron N. Invest Ophthalmol Vis Sci. 2014 Nov 18;55(12):7982-90. doi: 10.1167/iovs.14-15605.

ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes. Brines M, Dunne AN, van Velzen M, Proto PL, Ostenson CG, Kirk RI, Petropoulos IN, Javed S, Malik RA, Cerami A, Dahan A. Mol Med. 2015 Mar 13;20:658-66. doi: 10.2119/molmed.2014.00215.

The role of sodium channels in painful diabetic and idiopathic neuropathy. Lauria G, Ziegler D, Malik R, Merkies IS, Waxman SG, Faber CG; PROPANE Study group. Curr Diab Rep. 2014 Oct;14(10):538. doi: 10.1007/s11892-014-0538-5. Review.

Corneal confocal microscopy detects neuropathy in subjects with impaired glucose tolerance. Asghar O, Petropoulos IN, Alam U, Jones W, Jeziorska M, Marshall A, Ponirakis G, Fadavi H, Boulton AJ, Tavakoli M, Malik RA.     Diabetes Care. 2014 Sep;37(9):2643-6. doi: 10.2337/dc14-0279. Epub 2014 Jun 26.

Which test for diagnosing early human diabetic neuropathy? Malik RA. Diabetes. 2014 Jul;63(7):2206-8. doi: 10.2337/db14-0492. No abstract available. 

Fully automated, semiautomated, and manual morphometric analysis of corneal subbasal nerve plexus in individuals with and without diabetes.            Dehghani C, Pritchard N, Edwards K, Russell AW, Malik RA, Efron N.           Cornea. 2014 Jul;33(7):696-702. doi: 10.1097/ICO.0000000000000152.

Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome. Mojaddidi MA, Ahmed MS, Ali R, Jeziorska M, Al-Sunni A, Thomsen NO, Dahlin LB, Malik RA. Diabetologia. 2014 Aug;57(8):1711-9. doi: 10.1007/s00125-014-3271-3. Epub 2014 May 28.

2013

Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea.Yadav R, France M, Aghamohammadzadeh R, Liu Y, Hama S, Kwok S, Schofield J, Turkington P, Syed AA, Malik R, Pemberton P, Greenstein A, Durrington P, Ammori B, Gibson M, Jeziorska M, Soran H.           J Clin Endocrinol Metab. 2014 Sep;99(9):3390-8. doi: 10.1210/jc.2013-3939. Epub 2014 May 13.

Characteristics of a large cohort of patients with diabetes having at-risk feet and outcomes in patients with foot ulceration referred to a tertiary care diabetes unit. Riaz M, Miyan Z, Zaidi SI, Alvi SF, Fawwad A, Ahmadani MY, Zafar AB, Malik RA, Basit A. Int Wound J. 2016 Oct;13(5):594-9. doi: 10.1111/iwj.12289. Epub 2014 May 2.

Morphometric stability of the corneal subbasal nerve plexus in healthy individuals: a 3-year longitudinal study using corneal confocal microscopy. Dehghani C, Pritchard N, Edwards K, Vagenas D, Russell AW, Malik RA, Efron N. Invest Ophthalmol Vis Sci. 2014 Apr 24;55(5):3195-9. doi: 10.1167/iovs.14-13959.

Why are there no good treatments for diabetic neuropathy? Malik RA.      Lancet Diabetes Endocrinol. 2014 Aug;2(8):607-9. doi: 10.1016/S2213-8587(14)70067-1. Epub 2014 Apr 17. No abstract available. 

Longitudinal assessment of neuropathy in type 1 diabetes using novel ophthalmic markers (LANDMark): study design and baseline characteristics.            Pritchard N, Edwards K, Dehghani C, Fadavi H, Jeziorska M, Marshall A, Petropoulos IN, Ponirakis G, Russell AW, Sampson GP, Shahidi AM, Srinivasan S, Tavakoli M, Vagenas D, Malik RA, Efron N.       Diabetes Res Clin Pract. 2014 May;104(2):248-56. doi: 10.1016/j.diabres.2014.02.011. Epub 2014 Feb 20.

From the bedside to the bench and back again, with corneal confocal microscopy. Malik RA. Invest Ophthalmol Vis Sci. 2014 Mar 3;55(3):1231. doi: 10.1167/iovs.14-14095. No abstract available. 

Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal microscopy. Petropoulos IN, Alam U, Fadavi H, Marshall A, Asghar O, Dabbah MA, Chen X, Graham J, Ponirakis G, Boulton AJ, Tavakoli M, Malik RA. Invest Ophthalmol Vis Sci. 2014 Apr 3;55(4):2071-8. doi: 10.1167/iovs.13-13787.

Development and validation of the QUT corneal nerve grading scale. Efron N, Lee G, Lim RN, Qiu A, Thea E, Ton T, Wu G, Malik RA, Pritchard N. Cornea. 2014 Apr;33(4):376-81. doi: 10.1097/ICO.0000000000000084.

Have we reached the limits for the treatment of diabetic nephropathy?     Hajhosseiny R, Khavandi K, Jivraj N, Mashayekhi S, Goldsmith DJ, Malik RA.      Expert Opin Investig Drugs. 2014 Apr;23(4):511-22. doi: 10.1517/13543784.2014.892580. Epub 2014 Feb 21. Review.

Differential effects of different vitamin D replacement strategies in patients with diabetes.  Alam U, Chan AW, Buazon A, Van Zeller C, Berry JL, Jugdey RS, Asghar O, Cruickshank JK, Petropoulos IN, Malik RA. J Diabetes Complications. 2014 Jan-Feb;28(1):66-70. doi: 10.1016/j.jdiacomp.2013.09.003. Epub 2013 Oct 16.

Corneal confocal microscopy to assess diabetic neuropathy: an eye on the foot. Tavakoli M, Petropoulos IN, Malik RA. J Diabetes Sci Technol. 2013 Sep 1;7(5):1179-89. Review.

Evaluation of contact lens-induced changes in keratoconic corneas using in vivo confocal microscopy. Bitirgen G, Ozkagnici A, Malik RA, Oltulu R. Invest Ophthalmol Vis Sci. 2013 Aug 9;54(8):5385-91. doi: 10.1167/iovs.13-12437.

Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. Petropoulos IN, Alam U, Fadavi H, Asghar O, Green P, Ponirakis G, Marshall A, Boulton AJ, Tavakoli M, Malik RA. Diabetes Care. 2013 Nov;36(11):3646-51. doi: 10.2337/dc13-0193. Epub 2013 Jul 22.

Effects of bariatric surgery on human small artery function: evidence for reduction in perivascular adipocyte inflammation, and the restoration of normal anticontractile activity despite persistent obesity.   Aghamohammadzadeh R, Greenstein AS, Yadav R, Jeziorska M, Hama S, Soltani F, Pemberton PW, Ammori B, Malik RA, Soran H, Heagerty AM. J Am Coll Cardiol. 2013 Jul 9;62(2):128-135. doi: 10.1016/j.jacc.2013.04.027. Epub 2013 May 9.

Reply: To PMID 16303938. Edwards K, Pritchard N, Gosschalk K, Sampson GP, Russell A, Malik RA, Efron N. Cornea. 2013 Jul; 32(7): e179-80. doi: 10.1097/ICO.0b013e31828a282a. No abstract available. 

Repeatability of in vivo corneal confocal microscopy to quantify corneal nerve morphology. Petropoulos IN, Manzoor T, Morgan P, Fadavi H, Asghar O, Alam U, Ponirakis G, Dabbah MA, Chen X, Graham J, Tavakoli M, Malik RA. Cornea. 2013 May;32(5): e83-9. doi: 10.1097/ICO.0b013e3182749419.

2012

Wide-field assessment of the human corneal subbasal nerve plexus in diabetic neuropathy using a novel mapping technique. Edwards K, Pritchard N, Gosschalk K, Sampson GP, Russell A, Malik RA, Efron N. Cornea. 2012 Sep;31(9):1078-82.

Corneal confocal microscopy detects early nerve regeneration in diabetic neuropathy after simultaneous pancreas and kidney transplantation. Tavakoli M, Mitu-Pretorian M, Petropoulos IN, Fadavi H, Asghar O, Alam U, Ponirakis G, Jeziorska M, Marshall A, Efron N, Boulton AJ, Augustine T, Malik RA. Diabetes. 2013 Jan;62(1):254-60. doi: 10.2337/db12-0574. Epub 2012 Sep 21.

Corneal confocal microscopy detects small-fiber neuropathy in Charcot-Marie-Tooth disease type 1A patients. Tavakoli M, Marshall A, Banka S, Petropoulos IN, Fadavi H, Kingston H, Malik RA. Muscle Nerve. 2012 Nov;46(5):698-704. doi: 10.1002/mus.23377. Epub 2012 Sep 19.

Characteristics and outcomes of subjects with diabetic foot ulceration. Riaz M, Miyan Z, Zaidi SI, Alvi SF, Fawwad A, Ahmadani MY, Zafar AB, Malik RA, Basit A. Diabetes Care. 2012 Sep;35(9):e63. doi: 10.2337/dc11-1906. No abstract available. 

Carotid intima-media thickness: ultrasound measurement, prognostic value and role in clinical practice. Nair SB, Malik R, Khattar RS. Postgrad Med J. 2012 Dec;88(1046):694-9. doi: 10.1136/postgradmedj-2011-130214. Epub 2012 Jul 3. Review.

Assessing corneal nerve structure and function in diabetic neuropathy. Tavakoli M, Petropoulos IN, Malik RA. Clin Exp Optom. 2012 May;95(3):338-47. doi: 10.1111/j.1444-0938.2012.00743.x. Review.

Utility of corneal confocal microscopy for assessing mild diabetic neuropathy: baseline findings of the LANDMark study. Edwards K, Pritchard N, Vagenas D, Russell A, Malik RA, Efron N. Clin Exp Optom. 2012 May;95(3):348-54. doi: 10.1111/j.1444-0938.2012.00740.x. Epub 2012 Apr 29.

Corneal sensitivity is related to established measures of diabetic peripheral neuropathy. Pritchard N, Edwards K, Vagenas D, Russell AW, Malik RA, Efron N. Clin Exp Optom. 2012 May;95(3):355-61. doi: 10.1111/j.1444-0938.2012.00729.x. Epub 2012 Apr 10.

Optimal image sample size for corneal nerve morphometry. Vagenas D, Pritchard N, Edwards K, Shahidi AM, Sampson GP, Russell AW, Malik RA, Efron N. Optom Vis Sci. 2012 May;89(5):812-7. doi: 10.1097/OPX.0b013e31824ee8c9.

Effects of diabetes and hypertension on structure and distensibilty of human small coronary arteries. Lynch FM, Izzard AS, Austin C, Prendergast B, Keenan D, Malik RA, Heagerty AM. J Hypertens. 2012 Feb;30(2):384-9. doi: 10.1097/HJH.0b013e32834e38a0.

2011

Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJ. Diabetes Care. 2011 Oct;34(10):2220-4. doi: 10.2337/dc11-1108. Epub 2011 Aug 18.

Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy. Banerjee M, Anderson SG, Malik RA, Austin CE, Cruickshank JK.  Clin Sci (Lond). 2012 Jan;122(2):53-61. doi: 10.1042/CS20110033.

Corneal markers of diabetic neuropathy.  Pritchard N, Edwards K, Shahidi AM, Sampson GP, Russell AW, Malik RA, Efron N.Ocul Surf. 2011 Jan;9(1):17-28. Review.

Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat. Withers SB, Agabiti-Rosei C, Livingstone DM, Little MC, Aslam R, Malik RA, Heagerty AM. Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):908-13. doi: 10.1161/ATVBAHA.110.221705. Epub 2011 Jan 27.

Corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies. Tavakoli M, Malik RA.  J Vis Exp. 2011 Jan 3;(47). pii: 2194. doi: 10.3791/2194.

2010

Reply to letter from Dr Zhivov and Dr Stachs. Efron N, Tavakoli M, Boulton AJ, Malik R. Cont Lens Anterior Eye. 2011 Apr;34(2):99. doi: 10.1016/j.clae.2010.12.004. Epub 2011 Jan 6. No abstract available. 

Corneal sensitivity as an ophthalmic marker of diabetic neuropathy. Pritchard N, Edwards K, Vagenas D, Shahidi AM, Sampson GP, Russell AW, Malik RA, Efron N. Optom Vis Sci. 2010 Dec;87(12):1003-8. doi: 10.1097/OPX.0b013e3181fd6188.

Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P; Toronto Diabetic Neuropathy Expert Group.. Diabetes Care. 2010 Oct;33(10):2285-93. doi: 10.2337/dc10-1303. Review. Erratum in: Diabetes Care. 2010 Dec;33(12):2725. 

Repeatability of measuring corneal subbasal nerve fiber length in individuals with type 2 diabetes. Efron N, Edwards K, Roper N, Pritchard N, Sampson GP, Shahidi AM, Vagenas D, Russell A, Graham J, Dabbah MA, Malik RA. Eye Contact Lens. 2010 Sep;36(5):245-8. doi: 10.1097/ICL.0b013e3181eea915.

Cerebrovascular damage in late-life depression is associated with structural and functional abnormalities of subcutaneous small arteries. Greenstein AS, Paranthaman R, Burns A, Jackson A, Malik RA, Baldwin RC, Heagerty AM. Hypertension. 2010 Oct;56(4):734-40. doi: 10.1161/HYPERTENSIONAHA.110.152801. Epub 2010 Aug 16.

Diabetic gastroparesis: Therapeutic options. Alam U, Asghar O, Malik RA. Diabetes Ther. 2010 Aug;1(1):32-43. doi: 10.1007/s13300-010-0010-8. Epub 2010 Oct 26.

Vascular function in older adults with depressive disorder. Paranthaman R, Greenstein AS, Burns AS, Cruickshank JK, Heagerty AM, Jackson A, Malik RA, Scott ML, Baldwin RC. Biol Psychiatry. 2010 Jul 15;68(2):133-9. doi: 10.1016/j.biopsych.2010.04.017.

Exploring retinal and functional markers of diabetic neuropathy.    Shahidi AM, Sampson GP, Pritchard N, Edwards K, Russell A, Malik RA, Efron N. Clin Exp Optom. 2010 Sep;93(5):309-23. doi: 10.1111/j.1444-0938.2010.00491.x. Epub 2010 Jun 23. Review.

Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Tavakoli M, Quattrini C, Abbott C, Kallinikos P, Marshall A, Finnigan J, Morgan P, Efron N, Boulton AJ, Malik RA. Diabetes Care. 2010 Aug;33(8):1792-7. doi: 10.2337/dc10-0253. Epub 2010 Apr 30.

Novel insights on diagnosis, cause and treatment of diabetic neuropathy: focus on painful diabetic neuropathy. Tavakoli M, Asghar O, Alam U, Petropoulos IN, Fadavi H, Malik RA. Ther Adv Endocrinol Metab. 2010 Apr;1(2):69-88. doi: 10.1177/2042018810370954.

Explanations for the lower rates of diabetic neuropathy in Indian Asians versus Europeans. Abbott CA, Chaturvedi N, Malik RA, Salgami E, Yates AP, Pemberton PW, Boulton AJ. Diabetes Care. 2010 Jun;33(6):1325-30. doi: 10.2337/dc09-2067. Epub 2010 Mar 9.

Neuropathy of impaired glucose tolerance and its measurement. Boulton AJ, Malik RA. Diabetes Care. 2010 Jan;33(1):207-9. doi: 10.2337/dc09-1728. No abstract available. 

2009

Corneal confocal microscopy: a novel noninvasive means to diagnose neuropathy in patients with Fabry disease.          Tavakoli M, Marshall A, Thompson L, Kenny M, Waldek S, Efron N, Malik RA. Muscle Nerve. 2009 Dec;40(6):976-84. doi: 10.1002/mus.21383.

Corneal confocal microscopy: a novel means to detect nerve fibre damage in idiopathic small fibre neuropathy. Tavakoli M, Marshall A, Pitceathly R, Fadavi H, Gow D, Roberts ME, Efron N, Boulton AJ, Malik RA. Exp Neurol. 2010 May;223(1):245-50. doi: 10.1016/j.expneurol.2009.08.033. Epub 2009 Sep 11.

Reduced myelinated nerve fibre and endoneurial capillary densities in the forearm of diabetic and non-diabetic patients with carpal tunnel syndrome. Thomsen NO, Mojaddidi M, Malik RA, Dahlin LB. Acta Neuropathol. 2009 Dec;118(6):785-91. doi: 10.1007/s00401-009-0578-0.

Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease.      Wu F, Reed AA, Williams SE, Loh NY, Lippiat JD, Christie PT, Large O, Bettinelli A, Dillon MJ, Goldraich NP, Hoppe B, Lhotta K, Loirat C, Malik R, Morel D, Kotanko P, Roussel B, Rubinger D, Schrander-Stumpel C, Serdaroglu E, Nesbit MA, Ashcroft F, et al. Nephron Physiol. 2009;112(4):p53-62. doi: 10.1159/000225944. Epub 2009 Jun 20.

2008

Diabetic cardiomyopathy--a distinct disease? Khavandi K, Khavandi A, Asghar O, Greenstein A, Withers S, Heagerty AM, Malik RA. Best Pract Res Clin Endocrinol Metab. 2009 Jun;23(3):347-60. doi: 10.1016/j.beem.2008.10.016. Review.

Eutrophic remodeling of small arteries in type 1 diabetes mellitus is enabled by metabolic control: a 10-year follow-up study. Greenstein AS, Price A, Sonoyama K, Paisley A, Khavandi K, Withers S, Shaw L, Paniagua O, Malik RA, Heagerty AM.    Hypertension. 2009 Jul;54(1):134-41. doi: 10.1161/HYPERTENSIONAHA.109.129718. Epub 2009 May 26.

Diabetic cardiomyopathy. Asghar O, Al-Sunni A, Khavandi K, Khavandi A, Withers S, Greenstein A, Heagerty AM, Malik RA. Clin Sci (Lond). 2009 May;116(10):741-60. doi: 10.1042/CS20080500. Review.

Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients.  Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, Laing I, Yates AP, Pemberton PW, Malik RA, Heagerty AM. Circulation. 2009 Mar 31;119(12):1661-70. doi: 10.1161/CIRCULATIONAHA.108.821181. Epub 2009 Mar 16.

Abnormal LDIflare but normal quantitative sensory testing and dermal nerve fiber density in patients with painful diabetic neuropathy. Krishnan ST, Quattrini C, Jeziorska M, Malik RA, Rayman G. Diabetes Care. 2009 Mar;32(3):451-5. doi: 10.2337/dc08-1453. Epub 2008 Dec 15.

Myogenic tone and small artery remodelling: insight into diabetic nephropathy.   Khavandi K, Greenstein AS, Sonoyama K, Withers S, Price A, Malik RA, Heagerty AM.       Nephrol Dial Transplant. 2009 Feb;24(2):361-9. doi: 10.1093/ndt/gfn583. Epub 2008 Nov 21. Review. No abstract available. 

Early detection of nerve damage and repair in diabetic neuropathy. Malik RA. Nat Clin Pract Neurol. 2008 Dec;4(12):646-7. doi: 10.1038/ncpneuro0938. Epub 2008 Nov 18.

Management of painful diabetic neuropathy. Tavakoli M, Malik RA. Expert Opin Pharmacother. 2008 Dec;9(17):2969-78. doi: 10.1517/14656560802498149 . Review.

Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options. Veves A, Backonja M, Malik RA.    Pain Med. 2008 Sep;9(6):660-74. Review.

Pathophysiology and treatment of painful diabetic neuropathy.     Tavakoli M, Mojaddidi M, Fadavi H, Malik RA. Curr Pain Headache Rep. 2008 Jun;12(3):192-7. Review.

Neuropathy in diabetes: not a knee-jerk diagnosis. Rogers LC, Bevilacqua NJ, Malik RA, Armstrong DG. J Am Podiatr Med Assoc. 2008 Jul-Aug;98(4):322-5.

Clinical applications of corneal confocal microscopy. Tavakoli M, Hossain P, Malik RA.      Clin Ophthalmol. 2008 Jun;2(2):435-45.

Detection of medullary thyroid cancer with MIBG imaging for pheochromocytoma. Newton TD, Augustine T, Arumugam P, Malik RA. Clin Nucl Med. 2008 May;33(5):328-9. doi: 10.1097/RLU.0b013e31816a7a4d.

2007

Alstrom syndrome (OMIM 203800): a case report and literature review.    Joy T, Cao H, Black G, Malik R, Charlton-Menys V, Hegele RA, Durrington PN.      Orphanet J Rare Dis. 2007 Dec 21;2:49. Review.

Reduced vascular endothelial growth factor expression and intra-epidermal nerve fiber loss in human diabetic neuropathy. Quattrini C, Jeziorska M, Boulton AJ, Malik RA.        Diabetes Care. 2008 Jan;31(1):140-5. Epub 2007 Oct 12.

Neurovascular factors in wound healing in the foot skin of type 2 diabetic subjects. Krishnan ST, Quattrini C, Jeziorska M, Malik RA, Rayman G. Diabetes Care. 2007 Dec;30(12):3058-62. Epub 2007 Sep 26.

Corneal confocal microscopy detects early nerve regeneration after pancreas transplantation in patients with type 1 diabetes. Mehra S, Tavakoli M, Kallinikos PA, Efron N, Boulton AJ, Augustine T, Malik RA. Diabetes Care. 2007 Oct;30(10):2608-12. Epub 2007 Jul 10.

Surrogate markers of small fiber damage in human diabetic neuropathy.   Quattrini C, Tavakoli M, Jeziorska M, Kallinikos P, Tesfaye S, Finnigan J, Marshall A, Boulton AJ, Efron N, Malik RA. Diabetes. 2007 Aug;56(8):2148-54. Epub 2007 May 18.

Corneal sensitivity is reduced and relates to the severity of neuropathy in patients with diabetes. Tavakoli M, Kallinikos PA, Efron N, Boulton AJ, Malik RA.         Diabetes Care. 2007 Jul;30(7):1895-7. Epub 2007 Mar 19. No abstract available. 

Technique of the sural nerve biopsy. Bevilacqua NJ, Rogers LC, Malik RA, Armstrong DG.  J Foot Ankle Surg. 2007 Mar-Apr;46(2):139-42.

Impaired skin microvascular reactivity in painful diabetic neuropathy. Quattrini C, Harris ND, Malik RA, Tesfaye S. Diabetes Care. 2007 Mar;30(3):655-9.

Malignant melanoma misdiagnosed as a diabetic foot ulcer. Rogers LC, Armstrong DG, Boulton AJ, Freemont AJ, Malik RA. Diabetes Care. 2007 Feb;30(2):444-5. No abstract available. 

2006

Glycaemic control in south Asian patients during feasting and fasting. Asghar O, Greenstein A, Malik RA. Br J Hosp Med (Lond). 2006 Oct;67(10):523-6. Review. No abstract available. 

The Biogun: A novel way of eradicating methicillin-resistant Staphylococcus aureus colonization in diabetic foot ulcers.            Dang CN, Anwar R, Thomas G, Prasad YD, Boulton AJ, Malik RA. Diabetes Care. 2006 May;29(5):1176. No abstract available. 

2005

Recent developments in the assessment of efficacy in clinical trials of diabetic neuropathy. Mojaddidi M, Quattrini C, Tavakoli M, Malik RA.   Curr Diab Rep. 2005 Dec;5(6):417-22. Review.

Early detection of diabetic peripheral neuropathy with corneal confocal microscopy. Hossain P, Sachdev A, Malik RA. Lancet. 2005 Oct 15-21;366(9494):1340-3. No abstract available. 

Current and future strategies for the management of diabetic neuropathy. Malik RA. Treat Endocrinol. 2003;2(6):389-400. Review.

Diabetic neuropathies: a statement by the American Diabetes Association. Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D; American Diabetes Association. Diabetes Care. 2005 Apr;28(4):956-62. Review. No abstract available. 

Effects of angiotensin type-1 receptor antagonism on small artery function in patients with type 2 diabetes mellitus. Malik RA, Schofield IJ, Izzard A, Austin C, Bermann G, Heagerty AM. Hypertension. 2005 Feb;45(2):264-9. Epub 2005 Jan 3.

2004

Diabetic cardiomyopathy: mechanisms, diagnosis and treatment. Hayat SA, Patel B, Khattar RS, Malik RA. Clin Sci (Lond). 2004 Dec;107(6):539-57. Review.

Diabetic somatic neuropathies. Boulton AJ, Malik RA, Arezzo JC, Sosenko JM. Diabetes Care. 2004 Jun;27(6):1458-86. Review. No abstract available. 

Corneal nerve tortuosity in diabetic patients with neuropathy. Kallinikos P, Berhanu M, O'Donnell C, Boulton AJ, Efron N, Malik RA. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):418-22.

2003

Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. MalikRA, KallinikosP, AbbottCA, vanSchieCHM, MorganP, EfronN, BoultonAJM. Diabetologia. 2003 May;46(5):683-8. 

Endoneurial capillary abnormalities presage deterioration of glucose tolerance and accompany peripheral neuropathy in man. Thrainsdottir S, Malik RA,Dahlin LB, Wiksell P, Eriksson KF, Rosén I, et al. Diabetes. 2003;52(10):2615-22. 

2002

Focal and multifocal neuropathies. Malik RA. Curr Diab Rep. 2002 Dec;2(6):489-94. Review.

Vascular structural and functional changes in type 2 diabetes mellitus: evidence for the roles of abnormal myogenic responsiveness and dyslipidemia. Schofield I, Malik R, Izzard A, Austin C, Heagerty A. Circulation. 2002 Dec 10;106(24):3037-43.

Offloading diabetic foot wounds using the scotchcast boot: a retrospective study. Knowles EA, Armstrong DG, Hayat SA, Khawaja KI, Malik RA, Boulton AJ. Ostomy Wound Manage. 2002 Sep;48(9):50-3.

Angiotensin-converting enzyme inhibitors: are there credible mechanisms for beneficial effects in diabetic neuropathy? Malik RA, Tomlinson DR. Int Rev Neurobiol. 2002;50:415-30. Review. No abstract available.

2001

Sural nerve fibre pathology in diabetic patients with mild neuropathy: relationship to pain, quantitative sensory testing and peripheral nerve electrophysiology. Malik RA, Veves A, Walker D, Siddique I, Lye RH, Schady W, Boulton AJ. Acta neuropathologica. 2001 Apr;101(4):367-74. 

Nerve pathology in the type 1 diabetic dog: effects of treatment with sulindac. Journal of the peripheral nervous system. Walker D, Siddique I, Anderson H, Gardiner TA, Archer DB, Boulton AJM, Malik RA. 2001 Dec;6(4):219-26.

Atrial flutter: the dangers of cardioversion. International journal of cardiology. Charalambous C, Malik RA, Davies M, Heagerty AM. 2001 Nov;81(1):93-5.

2000

Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy. Khawaja KI, Walker D, Hayat SA, Boulton AJ, Malik RA. Diabetic medicine. 2000 Feb;17(2):163-6. 

1999

Perineurial abnormalities in the spontaneously diabetic dog. Ghani M, Malik RA, Walker D, Sharma AK, Lowrie CT, Schall WD, Boulton AJ. Acta neuropathologica. 1999 Jan;97(1):98-102.

Aortic dissection with chronic haemopericardium. Charalambous CP, Malik RA, Schofield I, Arya S, Heagerty AM. Journal of the Royal Society of Medicine. 1999 Dec;92(12):638- 9. 

Structural abnormalities do not explain the early functional abnormalities in the peripheral nerves of the streptozotocin diabetic rat. Walker D, Carrington A, Cannan SA, Sawicki D, Sredy J, Boulton AJ, Malik RA. Journal of anatomy. 1999 Oct;195 ( Pt 3):419-27. 

Specific fiber deficits in sensorimotor diabetic polyneuropathy correspond to cytotoxicity against neuroblastoma cells of sera from patients with diabetes. PittengerGL, MalikRA, BurcusN, BoultonAJ, VinikAI. Diabetes care. 1999 Nov;22(11):1839-44. 

1998

Relationship of elevated urinary albumin excretion to components of the metabolic syndrome in non-insulin-dependent diabetes mellitus. Diabetes research and clinical practice. Abuaisha B, Kumar S, Malik RA, Boulton AJ. 1998 Feb;39(2):93-9. 

Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: randomised double-blind controlled trial. Malik RA, Williamson S, Abbott C, Carrington AL, Iqbal J, Schady W, Boulton AJM. The lancet. 1998 Dec 19- 26;352(9145):1978-81.

1997

The pathology of human diabetic neuropathy. Malik RA. Diabetes. 1997 Sep;46 Suppl 2:S50-3.

1996

Arterio-venous shunting and proliferating new vessels in acute painful neuropathy of rapid glycaemic control (insulin neuritis). Tesfaye S, Malik RA, Harris N, Jakubowski JJ, Mody C, Rennie IG, Ward JD. Diabetalogica. 1996 Mar;39(3):329-35. 

1995

Mendenhall's syndrome: clues to the aetiology of human diabetic neuropathy. Journal of neurology, neurosurgery, and psychiatry. Malik RA, Kumar S, Boulton AJ. 1995 Apr;58(4):493-5.

Microvascular response to tissue injury and capillary ultrastructure in the foot skin of type I diabetic patients. Rayman G, Malik RA, Sharma AK, Day JL. Clinical science (London, England: 1979). 1995 Nov;89(5):467-74. 

Diabetic polyneuropathy in controlled clinical trials: Consensus Report of the Peripheral Nerve Society. Peripheral Nerve Society Malik RA. Annals of neurology. 1995 Sep;38(3):478-82.

1994

IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls. Journal of clinical pathology. BansalAS,Abdul-KarimB, MalikRA, GouldingP, PumphreyRS, BoultonAJ, HoltPL, Wilson PB. 1994 Apr;47(4):300-2.

Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy. Malik RA, Tesfaye S, Thompson SD, Veves A, Hunter A, Sharma AK, Ward JD, Boulton AJ. Microvascular research. 1994 Sep;48(2):236-45.

1993 

Cellular and humoral immunity in patients with insulin-dependent diabetes. Bansal A, Wilson P, Pumphrey RH, Boulton AM, Malik RA, Hawke S, Harcourt G, Pantic N, Beeson D, Willcox N, Newsom-Davis J. The lancet. 1993 Jul;342(8865).

1992

Skin epidermal thickness and vascular density in type 1 diabetes. Malik RA, Metcalfe J, Sharma AK, Day JL, Rayman G. Diabetes medicine. 1992 1992;9(3):263-7.  

Endoneurial capillary abnormalities in mild human diabetic neuropathy. Journal of neurology, neurosurgery, and psychiatry. Malik RA, Veves A, Masson EA, Sharma AK, Ah-See AK, Schady W, Lye RH, Boulton AJ. 1992 Jul;55(7):557-61. 

Relationships between haemostatic factors and capillary morphology in human diabetic neuropathy. Ford I, Malik RA, Newrick PG, Preston FE, Ward JD, Greaves M. Thrombosis and haemostasis. 1992 Dec 7;68(6):628-33. 

Endoneurial localisation of microvascular damage in human diabetic neuropathy. Diabetologia. Malik RA, Tesfaye S, Thompson SD, Veves A, Sharma AK, Boulton AJ, Ward JD. 1993 May;36(5):454-9 (Reprint – Initial print 1992:35 Suppl.1).

1991

Morphological abnormalities in the sural nerve from patients with peripheral vascular disease. Rodriguez-Sanchez C, Medina Sanchez M, Malik RA, Ah-See AK, Sharma AK. Histology and histopathology. 1991 Jan;6(1):63-71. 

Neutrophil aldose reductase activity as a potential marker for neuropathy and cataract in diabetes. Dent MT, Veves A, Tebbs SE, Gonzalez AM, Malik RA, Boulton AJM, Ward JD, Wilson RM. Diabetic medicine. 1991 1991;8(10):911-6.

The relationship between sural nerve morphometric findings and measures of peripheral nerve function in mild diabetic neuropathy. Veves A, Malik RA, Lye RH, Masson EA, Sharma AK, Schady W, Boulton AJ. Diabetic medicine. 1991 Dec;8(10):917-21.  

1990

Hypoxic neuropathy: relevance to human diabetic neuropathy. Malik RA, Masson EA, Sharma AK, Lye RH, Ah-See AK, Compton AM, Tomlinson DR, Hanley SP, Boulton AJ. Diabetologia. 1990 May;33(5):311-8. 

1989

Microangiopathy in human diabetic neuropathy: relationship between capillary abnormalities and the severity of neuropathy. Malik RA, Newrick PG, Sharma AK, Jennings A, Ah-See AK, Mayhew TM, Jakubowski J, Boulton AJ, Ward JD. Diabetologi