research-student-2

Publications

1. Courjaret R, Dib M, Machaca K. (2016) Store-Operated Ca2+ Entry in Oocytes Modulate the Dynamics of IP3 -Dependent Ca2+ Release From Oscillatory to Tonic. Journal of Cellular Physiology. (epub.doi:10.1002/jcp.25513)
2. Courjaret R, Machaca K. (2016) Xenopus Oocyte As a Model System to Study Store-Operated Ca(2+) Entry (SOCE). Frontiers in Cell and Developmental Biology 4:66. (doi:10.3389/fcell.2016.00066)
3. Courjaret R, Hodeify R, Hubrack S, Ibrahim A, Dib M, Daas S, Machaca K. (2016) The Ca2+-activated Cl- channel Ano1 controls microvilli length and membrane surface area in the oocyte. Journal of Cell Science 129:2548-58. (doi:10.1242/jcs.188367)
4. Nader N, Courjaret R, Dib M, Kulkarni RP, Machaca K. (2016) Release from Xenopus oocyte prophase I meiotic arrest is independent of a decrease in cAMP levels or PKA activity. Development 143:1926-36. (doi:10.1242/dev.136168)
5. Schaefer-Ramadan S, Bendriss G, Hubrack S, Al-Abdulmalek A, Machaca K. (2016) A novel approach to the expression and purification of recombinant Xenopus Cdc25C. Protein Expression and Purification 120:148-52. (doi:10.1016/j.pep.2015.12.007)
6. Hodeify R, Selvaraj S, Wen J, Arredouani A, Hubrack S, Dib M, Al-Thani SN, McGraw T, Machaca K. (2015) A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca²? influx levels. Journal of Cell Science 128:3143-54. (doi:10.1242/jcs.172320)
7. Nader N, Dib M, Daalis A, Kulkarni RP, Machaca K. (2014) Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest. Developmental Biology 395:355-66. (doi:10.1016/j.ydbio.2014.08.036)
8. Courjaret R, Machaca K. (2014) Mid-range Ca2+ signaling mediated by functional coupling between SOCE, SERCA and IP3 receptors. Nature Communications 5:3916. (doi:10.1038/ncomms4916)
9. Ullah A, Jung P, Ullah G, Machaca K. (2014) The role of IP3 receptor channel clustering in Ca2+ wave propagation during oocyte maturation. Progress in Molecular Biology and Translational Science 123:83-101. (doi:10.1016/B978-0-12-397897-4.00006-1)
10. Abou-Saleh H, Pathan AR, Daalis A, Hubrack S, Abou-Jassoum H, Al-Naeimi H, Rusch NJ, Machaca K. (2013) Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility. Journal of Biological Chemistry 288:32941-51. (doi:10.1074/jbc.M113.496802)
11. Courjaret R, Hubrack S, Daalis A, Dib M, Machaca K. (2013) The Xenopus TRPV6 homolog encodes a Mg2+-permeant channel that is inhibited by interaction with TRPC1. Journal of Cellular Physiology 228:2386-98. (doi:10.1002/jcp.24411)
12. Yu F, Sun L, Hubrack S, Selvaraj S, Machaca K. (2013) Intramolecular shielding maintains STIM1 in an inactive conformation. Journal of Cell Science 126:112401-10. (doi:10.1242/jcs.117200)
13. Lee B, Palermo G, Machaca K. (2013) Downregulation of store-operated Ca2+ entry during mammalian meiosis is required for the egg-to-embryo transition. Journal of Cell Science 126:1672-81. (doi:10.1242/jcs.121335)
14. Muallem S, Machaca K. (2013) Egg activation and the egg-to-embryo transition. Preface. Cell Calcium 53:1. (doi:10.1016/j.ceca.2012.12.002)
15. Nader N, Kulkarni RP, Dib M, Machaca K. (2013) How to make a good egg! The need for remodeling of oocyte Ca2+ signaling to mediate the egg-to-embryo transition. Cell Calcium 53:41-54. Review. (doi:10.1016/j.ceca.2012.11.015)
16. Haun S, Sun L, Hubrack S, Yule D, Machaca K. (2012) Phosphorylation of the rat Ins(1,4,5)P? receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P?. Channels (Austin) 6:379-84. (doi:10.4161/chan.21170)
17. Courjaret R, Machaca K. (2012) STIM1 and Orai1 in cellular proliferation and division. Frontiers in Bioscience 4:331-41. Review.
18. Sun L, Yu F, Ullah A, Hubrack S, Daalis A, Jung P, Machaca K. (2011) Endoplasmic reticulum remodeling tunes IP3-dependent Ca2+ release sensitivity. PLoS One 6:e27928. (doi:10.1371/journal.pone.0027928)
19. Yu F, Sun L, Courjaret R, Machaca K. (2011) Role of the STIM1 C-terminal domain in STIM1 clustering. Journal of Biological Chemistry 286:8375-84. (doi:10.1074/jbc.M110.188789)
20. Machaca K. (2010) Ca2+ signaling, genes and the cell cycle. Cell Calcium 48:243-50. Review. (doi:10.1016/j.ceca.2010.10.003)
21. Yu F, Sun L, Machaca K. (2010) Constitutive recycling of the store-operated Ca2+ channel Orai1, and its internalization during meiosis. Journal of Cell Biology 191:523-35. (doi: 10.1083/jcb.201006022)
22. Arredouani A, Yu F, Sun L, Machaca K. (2010) Regulation of store-operated Ca2+ entry during the cell cycle. Journal of Cell Science 123, 2155-62. Review. (doi:10.1242/jcs.069690)
23. Yu F, Sun L, Machaca K. (2009) Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis. Proceedings of the National Academy of Sciences 106:17401-6. (doi:10.1073/pnas.0904651106)
24. Sun L, Haun S, Jones RC, Edmondson RD, Machaca K. (2009) Kinase-dependent regulation of IP3-dependent Ca2+ release during oocyte maturation. Journal of Biological Chemistry 284:20184-96. (doi:10.1074/jbc.M109.004515)
25. El-Jouni W, Haun S, Machaca K.(2008) Internalization of plasma membrane Ca2+-ATPase during Xenopus oocyte maturation. Developmental Biology 324:99-107. (doi: 10.1016/j.ydbio.2008.09.007)
26. Sun L, Hodeify R, Haun S, Charlesworth A, MacNicol AM, Ponnappan S, Ponnappan U, Prigent C, Machaca K. (2008) Ca2+ homeostasis regulates Xenopus oocyte maturation. Biology of Reproduction 78:726-35.
27. El-Jouni W, Haun S, Hodeify R, Walker AH, Machaca K. (2007) Vesicular traffic at the cell membrane regulates oocyte meiotic arrest. Development 134:3307-15.
28. Machaca K. (2007) Ca2+ Signaling Differentiation during Oocyte Maturation. Journal of Cellular Physiology 213:331-40. Review.
29. Sun L, Chai Y, Hannigan R, Bhogaraju VK, Machaca K. (2007) Zinc regulates the ability of Cdc25C to activate MPF/cdk1. Journal of Cellular Physiology 213:98-104.
30. Ullah G, Jung P, Machaca K. (2007) Modeling Ca2+ signaling differentiation during oocyte maturation. Cell Calcium 42:556-64.
31. El-Jouni W, Jang B, Haun S, Machaca K. (2005) Calcium signaling differentiation during Xenopus oocyte maturation. Developmental Biology 288:514-25.
32. Wilkins C, Dishongh R, Moore SC, Whitt MA, Chow M, Machaca K. (2005) RNAi is an antiviral defence mechanism in Caenorhabditis elegans. Nature 436:1044-47.
33. Machaca K. (2004) Increased sensitivity and clustering of elementary Ca2+ release events during oocyte maturation. Developmental Biology 275:170-82.
34. Sun L, Machaca K. (2004) Ca2+cyt negatively regulates the initiation of oocyte maturation. Journal of Cell Biology 165:63-75.
35. Machaca K. (2003) Ca2+-calmodulin dependent protein kinase II potentiates store-operated Ca2+ current. Journal of Biological Chemistry 278:33730-37.
36. Machaca K, Haun S. (2002) Induction of maturation-promoting factor during Xenopus oocyte maturation uncouples Ca2+ store depletion from Store-Operated Ca2+ Entry. Journal of Cell Biology 156:75-86.
37. Machaca K, Haun S. (2000) Store Operated Calcium Entry inactivates at the germinal vesicle breakdown stage of Xenopus meiosis. Journal of Biological Chemistry 275:38710-15.