Multiple sclerosis study

Principal Investigators:
Prof. Rayaz Malik (Professor of Medicine & Senior Consultant, WCM-Q & HMC)
Dr. Saadat Kamran (Consultant Neurologists at HMC)

Dr. Ioannis Petropoulos (Post Doctoral Associate in Medicine)
Dr. Adnan Khan (Post Doctoral Associate in Medicine)
Mr. Georgios Ponirakis (Clinical Researcher)
Dr. Naveed Akhtar (Consultant Neurologists)
Prof. Ashfaq Shuaib (Director of Neuroscience Institute)
Dr Dirk Deleu (Senior Consultant and Head of Neurology & Neurophysiology)

Multiple Sclerosis (MS) is a progressive, chronic inflammatory, neurodegenerative disease and is the leading cause of neurological disability in young adults. Magnetic Resonance Imaging (MRI) is one of the most important para-clinical and research tools available for the diagnosis and monitoring of MS worldwide. However, the correlation between MRI measures of disease activity and clinical disease progression is weak. Retinal nerve fibre loss has been associated with optic neuritis, one of the manifestations of MS

We would like to examine whether more sophisticated MRI measures of brain atrophy (shrinkage) and nerve loss in the retina as well as corneal nerve loss may give us a better idea of disease severity and progression.


Figure 1. CCM images of a patient with MS showing a reduction in corneal nerves from the centre and inferior whorl (top) with a reduction in temporal retinal nerve fibre layer (RNFL) (bottom) and marked loss of corneal nerves in the centre and inferior whorl of the same patient from the eye with optic enuritis associated with more widespread reduction in RNFL (bottom) compared to the control.