QNL Auditorium , Level 2

Biological or clinical phenotypes arise from the biochemical state of a cell which, in turn, is the result of the composition and state of activity of biomolecules and their organization in the cell.

his presentation will provide an overview of our understanding of SARS-CoV-2 immunity based on a series of epidemiologic studies conducted in Qatar over the last three years.

Transcriptomics identifies mRNA levels, but not protein levels—yet whereas proteomics identifies protein levels, these do not necessarily reflect the biological activity of the protein

The detection of antibody serological markers by any immunoassay is widely used for early diagnosis, epidemiological surveillance, or evaluation of vaccine immunogenicity against many pathogens. Serological diagnosis of infectious diseases based on a single antigen is often challenging

Coronavirus disease of 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has sparked a global pandemic with severe complications and high morbidity rate. Neurological symptoms in COVID-19 patients, and neurological sequelae post COVID-19 recovery have been extensively reported.

Recent advances in technologies have enabled us to study the proteins circulating in human blood at a yet unprecedented depth and precision. We are now in an era to further unlock the potential of plasma proteomics and investigate its constituents at scale

Numerous studies have investigated the role of circulating proteins in COVID-19 disease using different proteomics platforms. In this talk, several studies using Olink technology will be presented

We live in the age of ‘omics. A wide variety of tools serving biomedical research have undergone revolutionary advancements, permitting the routine collection of unprecedented amounts of information from biological systems; whole genome sequencing is a ubiquitous example.

QNL Auditorium, Level 2

A highly complex pool of Immunoglobulin G (IgG) antibodies circulates in plasma that play an important role in the defense against bacteria. Such circulating IgG repertoires can contain a subset of protective IgG clones

Pneumococci colonize as harmless commensals the nasopharynx, while encountering as harmful pathogens the lungs, blood and CSF. By employing an in vivo pathoproteomics approach we recently identified pneumococcal antigens like ComDE and AliB essential for pneumococcal meningitis (Schmidt et al., 2019 PLoS Pathog 15: e1007987)

Tuberculosis disease (TB) remains a major global health challenge today, despite the availability of vaccine and an armoury of small molecule drugs. Notably, response rates to the century-old bacillus Calmette-Guerin (BCG) vaccine vary widely, for reasons that remain poorly understood

The molecular nanoscale organization of the surfaceome is a fundamental regulator of cellular signaling in health and disease. Technologies for mapping the spatial relationships of cell surface receptors and their extracellular signaling synapses 

Genome-wide association studies with proteomics are increasingly used to identify protein quantitative traits (pQTLs) that overlap with genetic loci of clinical interest and can inform decision-making in drug target prioritization and drug repurposing. Here we investigate issues related to pQTL identification by analyzing blood plasma samples from the multi-ethnic Qatar Metabolomics study on Diabetes (QMDiab) using the Seer Proteograph^TM MS-based proteomics platform.

In this talk, we will discuss various approach for the computational analysis and interpretation of multi-omics datasets, and their applications to biomedical and clinical research questions.

A critical and time-consuming part in omics projects is the analysis of the raw data generated in experiments. This should ideally be standardized, robust, and as automated as possible to save time and human resources.

In depth proteome coverage is one of the key challenges in the current biomarker field and comprehensive robust quantifications are key to any (multi-) omics approach. Plasma is the most easily accessible clinical specimen and it´s protein composition reports on a person’s well-being at the time point of collection.