Corneal Confocal Microscopy: a Surrogate Endpoint for Neurodegeneration in Clinical Trials


POSTPONED TO A LATER DATE TO BE ANNOUNCED

CCM in Autism

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Autism spectrum disorder (ASD) is a developmental disorder characterised by difficulty in communication and interaction with others. Most studies have focused on central alterations with postmortem studies showing cerebral neuronal loss and diffusion tensor imaging showing small fibre loss in face-perception and inter-hemispheric regions of the brain. However, recent studies show altered peripheral sensory perception thresholds and intraepidermal nerve fibre loss in ASD. Corneal confocal microscopy identifies distal corneal nerve fibre loss in children with ASD compared to children without ASD. Larger studies are required to determine the utility of CCM as a surrogate imaging biomarker for neuronal loss in relation to MRI abnormalities and behavioural alterations in patients with ASD.