Diabetes and oxidative stress research laboratory:

Peer Reviewed Publications:

  1. Ding H & 1Triggle CR (1Equal contribution). A review of endothelial dysfunction in diabetes: A focus on the contribution of a dysfunctional eNOS. 2010. [in press Journal of American Hypertension Society].
  2. Ding H & 1Triggle CR (1Equal contribution) Endothelial dysfunction in diabetes: Multiple sites and multiple targets for treatment. 2010. Pflugers Arch - Eur J Physiol. 459:977-994.
  3. Aljofan M, *Ding H. High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells. J Cell Physiol. 222(3):669-75. 2010.
  4. Bishara NB, *Ding H. Glucose enhances expression of TRPC1 and Ca entry in endothelial cells. Am J Physiol Heart Circ Physiol. 298(1):H171-8. 2010.
  5. Potocnik SJ, McSherry I, Ding H, Murphy TV, Kotecha N, Dora KA, Yuill KH, Triggle CR and Hill MA. Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: Role of EDH and K channels. Microcirculation, May 8:1-14, 2009.
  6. Potocnik SJ, McSherry I, Ding H, Murphy TV, Kotecha N, Dora KA, Yuill KH, Triggle CR and Hill MA. Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: Role of EDH and K channels. Microcirculation, May 8:1-14, 2009.
  7. Ellis Anthie, Zhong-Jian Cheng, Yang Li, Yanfen Jiang, Pannirselvam M, Hong Ding, Morley D. Hollenberg, and Chris Triggle. Effects of Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature. Eur. J. Pharmacol. 601: 111-117, 2008.
  8. *Ding, H., Aljofan, M., & Triggle, CR. Oxidative stress and increased eNOS and NADPH oxidase expression in cell cultures of mouse microvessel endothelial cells exposed to high glucose. J. Cell Physiol. 212(3):682-9. 2007.
  9. *Ding, H., Hashem, M., & Triggle, CR. Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: Changes in expression of NADPH oxidase subunits and eNOS. Eur. J. Pharmacol. 561:121-128. 2007.
  10. Ceroni, L., Ellis, A., Weihler, W.B., Ding, H., & Triggle, C.R. Connexin and calcium-activated potassium channel expression expression and EDHF in mouse mesenteric vasculature. Eur J. Pharmacology 560: 193-200, 2007.
  11. Ella S.M. Ng, Zhong-Jian Cheng, Anthie Ellis, Hong Ding, Yanfen Jiang Yang Li, Morley D. Hollenberg, and Chris Triggle. Nitrosothiol Stores in Vascular Tissue: Modulation by UV Light and Acetylcholine. Eur. J. Pharmacol. 560: 183-192, 2007.
  12. ZJ Cheng, Y Jiang, H. Ding, TJ Anderson, D Severson, CR. Triggle. Iincreased contribution of endothelium-derived contractile factor in Type 2 diabetic TallyHo mice: role for cytochrome P450 products. Can. J. Physiol & Pharmacol. 85(3-4):404-12. 2007.
  13. Wilson, A. Swan, J., Ding, H., Wilson, A., Whitbourn, R., Yii, M., Triggle, CR., Hill, MA., Best, J., Jenkins, A. Vascular Production of CRP and the Association Between Serum Levels and Plaque Deposition of CRP in Patients. Atherosclerosis. 191: 175-181. 2007.
  14. M. Pannirselvam, H. Ding, T.J Anderson and C.R Triggle. Pharmacological Characteristics of Endothelium-Derived Hyperpolarizing Factor-mediated Relaxation of Small Mesenteric Arteries from db/db mice. Eur J. Pharmacol. 551(1-3):98-107, 2006.
  15. *Ding, H., Hashem, M., Wiehler, W.B., Lau, W., Martin, J., Ried, J., Triggle, C.R. Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse. Br. J. Pharmacol.146: 1110-1118, 2005.
  16. *Ding H, Howarth AG, Pannirselvam M, Anderson TJ, Severson DL, Wiehler WB, Triggle CR, Tuana BS. Endothelial dysfunction in type 2 diabetes correlates with deregulated expression of the tail anchored membrane protein SLMAP. Am J Physiol Heart Circ Physiol. 289(1):H206-211, 2005.
  17. Chris R Triggle, Andrew Howarth, Zhong Jian Cheng, & Hong Ding. Twenty-five years since the discovery of EDRF: Does a dysfunctional endothelium contribute to the development of type 2 diabetes? Can. J. Physiol. & Pharmacol. 83: 681-700, 2005.
  18. Hong Ding & Chris R Triggle. Endothelial cell dysfunction and the vascular complications associated with type II diabetes: Assessing the health of the endothelium. Vascular Health and Risk Management 1: 55-71, 2005.
  19. Triggle CR, Ding H, Anderson TJ, Pannirselvam M. The endothelium in health and disease: A discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes. Mol Cell Biochem. 2004 263:21-27, 2004.
  20. Triggle CR, Hollenberg M, Anderson TJ, Ding H, Jiang Y, Ceroni L, Wiehler WB, Ellis A, Andrews K, McGuire JJ, Pannirselvan M. The endothelium in health and disease � A target for therapeutic intervention. Journal of Smooth Muscle Research. 39: 249-267, 2003.
  21. Triggle C. R. & Ding H. Endothelium-Dependent Hyperpolarizing Factor: Is there a novel chemical mediator? Clinical and Experimental Pharmacology and Physiology. 29:153-160, 2002.
  22. Ding H. & C.R. Triggle. Relaxing Blood Vessels: Are there novel endothelium-derived mediators to be found and can their discovery lead to the development of new therapeutic agents? Pharmaceutical News. 8: 42-49, 2001.
  23. McGuire J., H. Ding & C. R. Triggle. Endothelium-Derived Relaxing Factors � A Focus on Endothelium-Derived Hyperpolarizing Factor(s). Can J Physiol Pharmacol. 79: 443-470, 2001.
  24. *Ding H. & C.R. Triggle. Novel Endothelium-Derived Relaxing Factors: Identification Of Factors And Cellular Targets. J. Pharmacol. & Toxicol. Methods. 44: 441-452, 2000.
  25. Ding H., P. Kubes and C.R. Triggle. Potassium- and Acetylcholine-induced Vasorelaxation in Mice Lacking Endothelial Nitric Oxide Synthase. Br. J. Pharmacol. 129:1194-2000, 2000.
  26. Ding H., J. McGuire and C.R. Triggle. The Other Endothelium-Derived Relaxing Factor � A Review of Recent Findings Concerning the Nature and Cellular Actions of Endothelium-Derived Hyperpolarizing Factor (EDHF). Biomedical Research. 11: 119-129, 2000.
  27. Waldron G.J., Ding H., F. Lovren, P. Kubes and C.R. Triggle. Acetycholine-induced Relaxation of Peripheral Arteries Isolated From Mice Lacking Endothelial Nitric Oxide Synthase. Br. J. Pharmacol. 128:653-658, 1999.

*Corresponding Author

Book Chapters:

  1. Ding, H., Jiang, Y., Triggle, C.R. The contribution of d-tubocurarine and apamin-sensitive potassium channels to endothelium-derived hyperpolarizing factor-medaited relaxation of small mesenteric arteries from eNOS-/- mice. Proceedings of the Fourth International Workshop on Endothelium-DerivedHyperpolarizing Factor. EDHF 2002. Edited by Paul M. Vanhoutte, Taylor & Francis, London & New York pp. 283-296, 2003
  2. Triggle, C.R., Ding, H., Ng, E.S.N. Ellis, A. Nitric oxide (NO): synthesis and metabolism, tissue stores and the relationship of endothelium-derived NO to endothelium-dependent hyperpolarization. In: "Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine". Edited by R. Wang. Humana Press, 2004.
  3. Triggle, C.R., Pannirselvam, M., Anderson T.J & Ding, H. 2004. Endothelium-derived hyperpolarizing factor(s). Does it exist and what role does it play in the regulation of blood flow? Proceedings of the XVII ISHR World Congress of the International Society for Heart Research (Pathophysiology of Cardiovascular Disease, edited by. N.S. Dhalla, H. Rupp & A. Angel, & G.N. Pierce. Published by Kluwer Press, Boston, USA) July 06-11 2001, Winnipeg, Canada. pp341-348.
  4. Ding, H., & Triggle, C.R. Pharmacological characterization of potassium channels in intact mesenteric arteries and single smooth muscle cells from eNOS -/- and +/+ mouse. In Proceedings of the Third International Workshop on Endothelium-Derived Hyperpolarizing Factor. EDHF 2000. Edited by Paul M. Vanhoutte, Taylor & Francis, London & New York pp. 274-283, 2001.
  5. H. Ding & C. R. Triggle. Characterization of the KCa channels involved in the synthesis, release and action of EDHF and NO in mesenteric arterioles from eNOS expressing (+/+) and knock out (-/-) mice. In Proceedings of the 7th World Congress for Microcirculation 2001. 315-321