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Ali Chaari, PhD

Lecturer in Biochemistry

 +974 4492 8215 
alc2033@qatar-med.cornell.edu


Education

PhD, Biochemistry and Biophysics
Versailles University, France,  2012

Profile

Dr. Ali Chaari holds a degree in engineering biology from the National Engineering School in Tunisia and a PhD in biochemistry and biophysics from Versailles University, France where he studied the regulation of amyloid aggregation in neurodegenerative diseases. Subsequently, he conducted postdoctoral biochemistry research training at WCM-Q in the laboratory of Dr. Moncef Ladjimi.

During his PhD in France, Dr. Chaari began teaching biochemistry and molecular biology as a teaching assistant and also as a temporary assistant of education and research (ATER). When he joined WCM-Q as a post-doc he volunteered to teach  first year medical students. In 2015, Dr. Chaari decided to dedicate more time to teaching so he joined the biology support teaching team in the Division of Pre-medical Education.

In addition to his teaching role as a teaching specialist for biology and biochemistry courses, he is involved in several outreach programs and contributed to the development and delivery of the new pre-medical biochemistry curriculum. In the future, besides his current teaching duties, he will be developing and teaching a new biochemistry course.

Dr. Chaari is experienced in biochemistry, molecular biology, and biophysics. In 2015, he was awarded a grant from Qatar National Research Fund to lead a study on chaperone interaction with amylin peptide in type 2 diabetes. He has co-authored several original research articles, written two books and has presented his work at several conferences. In addition, he is active as a research mentor to WCM-Q's medical students. One area of active research is the study of amyloid proteins modulation in neurodegenerative diseases and diabetes.


Selected Publications

  • Chaari A, Eliezer D, Ladjimi M. The C-terminal alpha-helices of mammalian Hsc70 play a critical role in the stabilization of alpha-synuclein binding and inhibition of aggregation. Int J Biol Macromol. 2016 Feb;83:433-41. https://www.ncbi.nlm.nih.gov/pubmed/26601760
  • Chaari A, Fahy C, Chevillot-Biraud A, Rholam M. Insights into Kinetics of Agitation-Induced Aggregation of Hen Lysozyme under Heat and Acidic Conditions from Various Spectroscopic Methods. PloS one. 2015;10(11):e0142095. https://www.ncbi.nlm.nih.gov/pubmed/23562552
  • Chaari A, Hoarau-Vechot J, Ladjimi M. Applying chaperones to protein-misfolding disorders: molecular chaperones against alpha-synuclein in Parkinson's disease. Int J Biol Macromol. 2013 Sep;60:196-205. https://www.ncbi.nlm.nih.gov/pubmed/23748003
  • Chaari A, Horchani H, Frikha F, Verger R, Gargouri Y, Ladjimi M. Surface behavior of alpha-Synuclein and its interaction with phospholipids using the Langmuir monolayer technique: a comparison between monomeric and fibrillar alpha-Synuclein. Int J Biol Macromol. 2013 Jul;58:190-8. https://www.ncbi.nlm.nih.gov/pubmed/26571264
Books

  • Chaari A . Chaperones as a Novel Target Against Amyloids in Parkinson’s Disease: LAP LAMBERT Academic Publishing; 2014.

  • Chaari A. Produits Naturels VERSUS Amyloides et Amyloses: Produits naturels et maladies Dégénératives Presses Académiques Francophones; 2014.