Dr. Nayef A. Mazloum joined WCM-Q in January 2011. He comes from WCMC in New York where he served since 2008 as instructor of microbiology and immunology. He graduated from the American University of Beirut in 1994, continuing his studies at New York Medical College in Valhalla, graduating with a Ph.D. in Biochemistry and Molecular biology in 2003. He started his postdoctoral training at Memorial Sloan Kettering Cancer Center in New York before continuing at WCMC.
Dr. Nayef Mazloum is working to uncover the molecular mechanisms of human diseases. His research focus involves molecular aspects of DNA repair mechanisms as related to the stability of the genome and how the dysfunction of these regulatory pathways leads to disease onset. Specifically, he is interested in the interplay between DNA damage response proteins, DNA recombinases, DNA polymerases, and DNA helicases in the maintenance of genome integrity--a critical factor in preventing cancer and age-related disorders.
- Mazloum N, Stegman MA, Croteau DL, Van Houten B, Kwon NS, Ling Y, Dickinson C, Venugopal A, Towheed MA, Nathan C. Identification of a Chemical That Inhibits the Mycobacterial UvrABC Complex in Nucleotide Excision Repair. Biochemistry. 2011 Mar 1; 50(8):1329-35.
- Mazloum N, Holloman WK. Brh2 promotes a template-switching reaction enabling recombinational bypass of lesions during DNA synthesis. Molecular Cell. 2009 Nov 25; 36(4): 620-630.
- Mazloum N, Holloman WK. Second-end capture in DNA double-strand break repair promoted by Brh2 protein of Ustilago maydis. Molecular Cell. 2009 Jan 30; 33(2): 160-170.
- Mazloum N, Zhou Q, Holloman WK. D-loop formation by Brh2 protein of Ustilago maydis. Proceedings of the National Academy of Science of the United States of America. 2008 Jan 15; 105(2): 524-529.
- Mazloum N, Zhou Q, Holloman WK. DNA binding, annealing, and strand exchange activities of Brh2 protein from Ustilago maydis. Biochemistry. 2007 Jun 19; 46(24): 7163-7173.