research-labs

Publications

Most recent publications
  • Triggle CR, Ding H. Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium. Acta Physiol (Oxf). 2015 Dec 17. doi: 10.1111/apha.12644. [Epub ahead of print]. Invited review.
  • Arunachalam G, Lakshmanan AP, Samuel SM, Triggle CR, Ding H. Molecular interplay between microRNA-34a and sirtuin1 in hyperglycaemia-mediated impaired angiogenesis in endothelial cells: Effects of metformin. J. Pharmacol. Exp Ther.2016; 356(2):314-323. Published ahead of print November 18, 2015, doi:10.1124/jpet.115.226894
  • Ghosh S, Lakhsmanan AP, Mu Ji Hwang Mu J, Kubba H, Ahmed Mushannen A, Triggle CR, Ding H. Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions. Biochemical Pharmacology. 2015; 98(3):412-421.,
  • Triggle CR, Williams M. Challenges in the Biomedical Research Enterprise in the 21st century: Antecedents in the writings of David Triggle. Biochemical Pharmacol. 2015; 98(2):342-359.
  • Triggle CR. The answer is not 42. Biochemical Pharmacol. 2015; 98(2):327-334.
  • Kinaan M., Ding H., Triggle C. An Old Drug for the Treatment of Diabetes, but New as a Drug for the Protection of the Endothelium. Medical Principles and Practice. Invited Review. 2015;24(5):401-415.
  • Zhuofeng Lin, Xuebo Pan, Fan Wu, Dewei Ye, Yi Zhang, Yu Wang, Leigang Jin, Qizhou Lian, Yu Huang, Hong Ding, Chris Triggle, Kai Wang, Xiaokun Li, and Aimin Xu. Fibroblast growth factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. Circulation 2015;131(21): 1861-1871.
  • Arunachalam G., Upadhyay R., Ding H., Triggle CR. MicroRNA signature and cardiovascular dysfunction. J Cardiovascular Pharmacology. Invited Review. 2015; 65(5): 419-429.
  • Chris R. Triggle and Hong Ding. Cardiovascular impact of drugs used in the treatment of diabetes. Therapeutic Advances in Chronic Disease. Invited Review. 2014; 5:245-268.
  • Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KS, Xu A. FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting. Diabetes. 2014; 63(12): 4064-4075.
  • El-Daly M, Saifeddine M, Mihara K, Ramachandran R, Triggle CR, Hollenberg MD. Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways. Br J Pharmacol. 2014; 171(9):2413-2425.
  • Gnanapragasam Arunachalam, Samson Mathews Samuel, Isra Marei, Hong Ding and Chris R. Triggle Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. Br J Pharmacol. 2014; 171(2):523-535.
  • Triggle CR, Samuel SM, Ravishankar S, Marei I, Arunachalam G, Ding H. The endothelium: influencing vascular smooth muscle in many ways. Can. J. Physiology & Pharmacology 2012 90: 713-738 (Invited Review).
  • Basha B, Samuel, SM, Triggle CR, Ding H. Endothelial Dysfunction in Diabetes Mellitus: Possible Involvement of Endoplasmic Reticulum Stress? Experimental Diabetes Research, volume 2012, pp 1-14. E-Pub. doi: 10.1155/2012/481840
  • Xiaoliang C, Li Y, Hollenberg M, Triggle CR, Ding H. The contribution of d-tubocuraine and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS -/- mice. J Cardiovasc Pharmacol. 2012 59: 413-425.
  • Li Y, Mihara K, Saifeddine M, Krawetz A, Lau DC, Li H, Ding H, Triggle CR, Hollenberg MD. Perivascular adipose tissue-derived relaxing factors: Release by peptide agonists via proteinase-activated receptor-2 (PAR(2)) and non-PAR(2) mechanisms. Br J Pharmacol. 2011 164: 1990-2002. doi: 10.1111/j.1476-5381.2011.01501.x.
  • Ding H., Triggle CR. Endothelial dysfunction in diabetes: Multiple targets for treatment. Pfl�gers Archiv European J. Physiology 2010 459: 977-994 (Invited Review).
  • Triggle CR., Ding, H. A review of endothelial dysfunction in diabetes: A focus on the contribution of a dysfunctional eNOS. J. American Society of Hypertension 2010. 4: 102-115 (Invited Review).
  • Potocnik SJ., McSherry I., Ding H., Murphy TM., Kotecha N., Kim A. Dora KA., Sandow SL., Triggle CR., Hill MA. Endothelium-dependent vasodilation in myogenically-active mouse skeletal muscle arterioles: role of EDHF and K+ channels. Microcirculation 2009 16: 377-390.
  • Andrews KL., Irvine JC., Tare, M., Apostolopoulos, J., Favaloro, JL., Triggle CR., Kemp-Harper, BK. A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries. Br. J. Pharmacol 2009 157: 540-550.
  • Ellis A., Cheng Z-J. Li Y., Jiang Y-F., Yang, J., Pannirselvam M., Ding H., Hollenberg MD., Triggle, CR. Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature. Eur J. Pharmacol. 2008 601:111-117.
  • Triggle C.R. Defying the economists: A decrease in heart rate improves not only cardiac but also endothelial function. Br. J. Pharmacol. Invited Commentary. 2008 154: 727-728.
  • Young, E.J., Hill, M.A. Wiehler, W.B., Triggle, C.R., & Reid, J.J. Reduced EDHF responses and connexin activity in mesenteric arteries from the insulin-resistant obese Zucker rat. Diabetologia 2008 51: 872-881.
  • Triggle C.R. The early effects of elevated glucose on endothelial function as a target in the treatment of type 2 diabetes. Drugs of Today 2008 43: 815-826.
  • Zhong Jian Cheng, Yan-Fen Jiang, Hong Ding, David Severson, Chris R. Triggle. Iincreased contribution of endothelium-derived contractile factor in Type 2 diabetic TallyHo mice: role for cytochrome P450 products. Can. J. Physiol & Pharmacol. 2007 85: 404-412.
  • Ding, H., Hashem, M., Triggle, CR. Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: Changes in expression of NADPH oxidase subunits and eNOS. Eur. J. Pharmacol 2007 561: 121-128.
  • Ding, H., Aljofan, M., & Triggle, CR. Oxidative stress and increased eNOS and NADPH oxidase expression in cell cultures of mouse microvessel endothelial cells exposed to high glucose. J. Cell Physiol. 2007 212: 682-689.
  • Ceroni, L., Ellis, A., Weihler, W.B., Ding, H., & Triggle, C.R. Connexin and calcium-activated potassium channel expression expression and EDHF in mouse mesenteric vasculature. Eur J. Pharmacology 2007 560: 193-200.
  • Ella S.M. Ng, Zhong-Jian Cheng, Anthie Ellis, Hong Ding, Yanfen Jiang Yang Li, Morley D. Hollenberg, and Chris Triggle. Nitrosothiol Stores in Vascular Tissue: Modulation by UV Light and Acetylcholine. Eur J. Pharmacology 2007 560: 183-192.
  • Hill M, Triggle C, Best JD, Jenkins AJ. Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy. Atherosclerosis. 2007 191: 175-181.
  • Wilson AM, Swan JD, Ding H, Zhang Y, Whitbourn RJ, Gurry J, Yii M, Wilson AC, Triggle, CR. & Triggle, DJ. What is the future of peer review? Why is there fraud in science? Is plagiarism out of control? Why do scientists do bad things? Is it all a case of: �All that is necessary for the triumph of evil is that good men do nothing?� Vascular Health and Risk Management 2007 3: 39-53. (Invited Review).
  • Pannirselvam M, Ding H, Anderson TJ, Triggle CR. Pharmacological Characteristics of Endothelium-Derived Hyperpolarizing Factor-mediated Relaxation of Small Mesenteric Arteries from db/db mice. Eur J. Pharmacol. 2006 551: 98-107.
  • Dong H, Jiang Y-F, Triggle CR, Li X-F, Lytton, J. Novel Role for K+�dependent Na+/Ca2+ Exchangers (NCKX) in the Regulation of Cytosolic Free Ca2+ and Contractility of Arterial Smooth Muscle. Am J Physiology 2006 291: H1226-H1235.
  • Howarth AG, Berger J, Pannirselvam M, Jiang Y-F, SeversonD, AndersonTJ, Triggle CR. A non-thiazolidinedione PPARy agonist reverses endothelial dysfunction in diabetic (db/db -/-) mice. J Pharmacol. Exp. Ther. 2006.316: 364-370.
  • Triggle CR, Howarth A, Cheng ZJ, Hong Ding H. Twenty-five years since the discovery of EDRF: Does a dysfunctional endothelium contribute to the development of type 2 diabetes? Canadian Journal of Physiology & Pharmacology 2005;83:681-700.
  • Dusting G, Triggle CR. Are we over oxidized? Oxidative stress, cardiovascular disease and the future of intervention studies with antioxidants. Opinion Article, Vascular Health and Risk Management, In Press 2005;1: 93-96. (Invited Review)
  • Andrews K, Pannirselvam M, Anderson TJ, Jenkins AJ, Triggle CR, Hill,M. The Vascular Endothelium in Diabetes: A practical target for drug treatment? Expert Opinions Therapeutic Targets. 2005;9: 101-117.
  • Ding H, Hashem M, Wiehler, WB, Lau, W, Martin J, Ried J, Triggle CR. Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse. Br. J. Pharmacol. 2005. 146: 1110-1118.
  • Bishara, NB, Triggle CR, Hill, MA. Arachidonic Acid-Induced Ca2+ Entry in Cultured Bovine Endothelial Cells. Endothelium 2005;12: 153-161.
  • Ding H, Howarth AG, Pannirselvam M, Anderson TJ, Severson DL, Wiehler WB, Triggle CR, Tuana BS. Endothelial dysfunction in type 2 diabetes correlates with deregulated expression of the tail anchored membrane protein SLMAP. Am J Physiol Heart Circ Physiol. 2005;289(1): H206-H211.
  • 25. Pannirselvam M, Wiehler WB, Anderson TJ, Triggle, C.R. Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products. Br. J. Pharmacol. 2005;144, 953-960.
  • Triggle CR, Triggle DJ. From Gutenberg to Open Science: An Unfulfilled Odyssey. Drug Dev. Res. 2016. Oct 21. doi: 10.1002/ddr.21369.

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