research-labs

Publications

1. Editor-in-Chief and Managing Editor
2. Editorial
  • Florea AM, Büsselberg D, David Carpenter. Special Issue: “Metals and Disease”. Journal of Toxicology. Volume 2012, Article ID 825354, 2 pages. Hindawi Publishing Corporation doi:10.1155/2012/825354.
  • Carpenter DO, Büsselberg D. Editor’s Page: Introduction. Journal of Local and Global Health Science. Vol. 2013,5, Qscience. http://www.qscience.com/doi/pdf/10.5339/jlghs.2013.5
3. Peer-reviewed Articles
  • Shevtsova NA, Büsselberg D, Molkov VL, Bischoff AM, Smith JC, Richter DW and Rybak IA . Effects of glycinergic inhibition failure on respiratory rhythm and pattern generation. Progress in Brain Research (under review) 2013.
  • Florea AM and Büsselberg D. The two opposite facets of arsenic: Toxin and anticancer drug. Journal of Local and Global Health Science. 2013. http://dx.doi.org/10.5339/jlghs.2013.1
  • Florea AM and Büsselberg D. Breast cancer and possible mechanisms of therapy resistance. Journal of Local and Global Health Science. 2013. http://dx.doi.org/10.5339/jlghs.2013.2
  • Juntermanns B, Göpelt K, Büsselberg D. Modulation of the Respiratory Rhythm by Gap-Junction Blockers 18-a-Glycyrrhetinic Acid and 18-b-Glycyrrhetinic Acid. Indian Journal of Physiology and Pharmacology. 07/2013; 57(3): 214.
  • Florea AM, Taban J, Varghese E, Alost BT, Moreno S, Büsselberg D. Lead (Pb2+) Neurotoxicity: Ion-Mimicry with Calcium (Ca2+) Impairs Synaptic Transmission. A Review with Animated Illustrations of Pre- and Post-synaptic Lead Effects. Journal of Local and Global Health Science. 2013; http://dx.doi.org/10.5339/jlghs.2013.4
  • Shanmugam V, Wafi A, Al-Taweel N and Büsselberg D. Disruption of Circadian Rhythm Increases the Risk of Cancer, Metabolic Syndrome and Cardiovascular Disease A Review. Journal of Local and Global Health Science. 2013 http://dx.doi.org/10.5339/jlghs.2013.3
  • Hagenacker T, Schäfer N, Büsselberg D, Schäfers M. Analgesic ineffectiveness of lacosamide after spinal nerve ligation and its sodium channel activity in injured neurons. European Journal of Pain Article first published online: 11 DEC 2012 DOI: 10.1002/j.1532-2149.2012.00260.x.
  • Sadiq S, Ghazala Z, Chowdhury A, Büsselberg D. Metal toxicity at the synapse: presynaptic, postsynaptic and long-term effects. Journal of Toxicology, Special Issue "Metals and Disease" 2012:132671.Epub 2012 Jan 12.
  • Florea AM and Büsselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers 2011, 3(1), 1351-1371. http://www.mdpi.com/2072-6694/3/1/1351.
  • Hagenacker T, Ledwig D, Büsselberg D. Additive inhibitory effects of calcitonin and capsaicin on voltage activated calcium channel currents in nociceptive neurons of rat. Brain Research Bulletin. 2011 Apr 25;85(1-2):75-80. Epub 2011 Feb 16.
  • Florea AM, Büsselberg D. Metals and breast cancer: risk factors or healing agents? Journal of Toxicology. 2011(2011)159619. Epub 2011 Jul 24.
  • Hagenacker T, Ledwig D, Büsselberg D. Additive inhibitory effects of calcitonin and capsaicin on voltage activated calcium channel currents in nociceptive neurons of rat. Brain Research Bulletin. 2011 Apr 25;85(1-2):75-80.
  • Hagenacker T, Hillebrand I, Büsselberg D, Schäfers M. Myricetin reduces voltage activated potassium channel currents in DRG neurons by a p38 dependent mechanism. Brain Research Bulletin. 2010 Oct 30;83(5):292-6.
  • Hagenacker T, Hillebrand I, Wissmann A, Büsselberg D, Schäfers M. Anti-allodynic effect of the flavonoid myricetrin in a rat model of neuropathic pain: involvement of p38 and protein kinase C mediated modulation of Ca2+ channels. Pdf
  • Hagenacker T, Czschik JC, Schäfers M, Büsselberg D. Sensitization of voltage activated calcium channel currents for capsaicin in nociceptive neurons by tumor necrosis factor alpha. Brain Research Bulletin, 2010, 81(1): 157-163. Pdf
  • Greffrath W, Schwarz St T, Büsselberg D, Treede R-D. Heat-evoked action potential discharges in nociceptive primary sensory neurons of rats. J. Neurophysiology, 2009, 102(1):424-436. Pdf
  • Florea A-M, Büsselberg D. Anti-Cancer drugs interfere with calcium signaling. Neurotoxicology 2009, 30(5): 803-810. Pdf
  • Günes DA, Florea A-M Splettstoesser F, Büsselberg D. Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity. Neurotoxicology 2009, 30(2): 194-202. Pdf
  • Florea A-M, Büsselberg, D. Metallic compounds (arsenic trioxide and trimethyltin chloride) interact with calcium homeostasis and trigger cell death. Materialwissenschaft und Werkstofftechnik 2009, 40: 13-16. 
  • Tomaszewski A, Büsselberg D. SnCl2 reduces voltage gated calcium channel currents of dorsal root ganglion neurones of rats. Neurotoxicology 2008, 29: 958-963. Pdf
  • Florea A-M, Büsselberg D. Arsenic trioxide in environmentally and clinically relevant concentrations alters calcium homeostasis and induces cell type specific apoptosis in tumour and non-tumour cells. Toxicology letters 2008, 179: 34-42. Pdf
  • Czeschik JC, Hagenacker T, Schäfers M, Büsselberg D. TNF-a differentially modulates ion channels of nociceptive neurons. Neuroscience Letters 2008, 434: 293-298.Pdf
  • Hagenacker T, Ledwig D, Büsselberg D. Intracellular calcium ([Ca2+]i) influences pain sensation in peripheral nociceptive systems. Cell Calcium 2008, 43: 215-227. Pdf
  • Hagenacker T, Büsselberg D. Modulation of intracellular calcium [Ca2+]i influences capsaicin induced currents of TRPV-1 and voltage activated channel currents in nociceptive neurones. J. Pheripheral Nervous System 2007, 12:277-284. 
  • Splettstoesser F, Florea A-M, Büsselberg D. IP3-receptor-antagonist 2-APB attenuates cisplatin induced Ca2+-influx in HeLa-S3 cells and prevents activation of calpain. Brit. J Pharmacology 2007, 151: 1176-1186. Pdf
  • Florea A-M, Splettstoesser F, Büsselberg D. Mechanisms of arsenic trioxide (As2O3) induced calcium signals and cellular death in two human SY-5Y Neuroblastoma and 293 embryonic kidney (HEK) cells. TAAP 2007, 220: 292-301. Pdf
  • Tomaszewski A, Büsselberg D. Cisplatin modulates voltage gated channels in dorsal root ganglion neurones. Neurotoxicology 2007, 28: 49-58. Pdf
  • Florea A-M, Büsselberg D. Metals and metal compounds: occurrence, use, benefits and toxic cellular effects. Biometals 2006, 19: 419-427. Pdf
  • Florea A-M, Splettstoesser, F, Dopp, E, Rettenmeier AW, Büsselberg D. Modulation of calcium homeostasis by trimethyltin chloride in human tumor cells: Neuroblastoma SY5Y and cervix adenocarcinoma Hela S3. Toxicology. 2005, 216: 1-8.Pdf
  • Hagenacker T, Splettstoesser F, Greffrath W, Treede, R-D, Büsselberg D. Capsaicin blocks voltage-gated calcium channel currents of small DRG neurones. Brain Research 2005, 1062: 74-85. Pdf
  • Florea A-M, Büsselberg D. Toxic effects of metals: modulation of intracellular calcium homeostasis. Materialwissenschaft und Werkstofftechnik 2005, 36: 757-760. 
  • Florea A-M, Dopp E, Büsselberg D. Elevated calcium transients by trimehtyltin chloride in HeLa cells: types and levels of elevation. Cell Calcium 2005, 37: 251-258. Pdf
  • Splettstoesser F, Bonnet U, Wiemann M, Bingmann, D, Büsselberg D. Modulation of voltage gated channel currents by Harman and Harmaline Brit. J Phar-macoL 2005, 144: 52-58. Pdf
  • Büsselberg D, Bischoff AM, Richter D W. Failure of glycine inhibition changes bursting behaviour of respiratory neurones. Neuroscience 2003, 122/3: 831-841. Pdf
  • Mohanakumar KP, Samanta Ray S, Büsselberg D. The parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine on membrane currents and intra-synaptosomal calcium. Neuroscience Research Communications 2002, 30/1: 35-42. 
  • Dutschmann M, Bischoff AM, Richter DW, Büsselberg D. Histaminergic Modulation of the respiratory network via H1, H2 and H3 receptors analysed in an in situ mouse. Pflügers Archiv, European J. Physiology 2003, 445: 570-576. 
  • Büsselberg D, Bischoff, AM, Becker, K, Becker, C.-M, Richter DW. Respiratory rhythm in mutant oscillator mice (Glra 1spd-ot / Glra 1spd-ot). Neuroscience letters 2001, 316/2: 99-102. Pdf
  • Büsselberg D, Bischoff AM, Paton, JFR, Richter DW. Reorganisation of the respiratory network after loss of glycinergic inhibition. Pflügers Archiv, Eupean J. Physiology 2001,441: 444-449. Pdf
  • Schwarz S, Greffrath W, Büsselberg D, Treede R-D. Inactivation and tachy-phylaxis of heat-evoked inward currents in nociceptive primary sensory neurones in rats. J Physiology (Lond) 2000, 528 (3): 539-549. Pdf
  • Richter DW, Mironov SI, Büsselberg D, Lalley PM, Bischoff AM, Wilken B. Respiratory rhythm generation: plasticity of a neuronal network Neuroscientist 2000, 6(3): 181-198. 
  • Wiemann M, Schirrmacher K, Büsselberg D. Interference of lead with the calcium release activated calcium flux of osteoblast-like cells. Calcified Tissue Int. 1999, 65: 479-485. Pdf
  • Kirschstein T, Greffrath W, Büsselberg D, Treede R-D. Inhibition of rapid heat responses in nociceptive primary sensory neurones of the rat by vanilloid receptor antagonists. J Neurophysiol 1999, 82: 2853-2860. Pdf
  • Schirrmacher K, Büsselberg D, Langosch JM, Bingmann D. Effects of (±)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats. European J. Neuropsycopharmacol 1999, 9: 171-176. Pdf
  • Wiemann M, Büsselberg D, Schirrmacher K, Bingmann D. A calcium release activated calcium influx in primary cultures of rat osteoblast-like cells. Calcified Tissue Int. 1998, 63: 154-159. Pdf
  • Büsselberg D, Schirrmacher K, Domann R, Wiemann M. Lead interferes with calcium entry through Membrane pores. Fresenius´ J. Analyt. Chem 1998, 361: 372-376. Pdf
  • Schirrmacher K, Wiemann M, Bingmann D, Büsselberg D. Effects of lead, mercury and methyl-mercury on gap junctions and [Ca2+]i in bone cells. Calcified Tissue Int. 1998, 63:134-139. Pdf
  • Diewald L, Heimrich B, Büsselberg D, Watanabe T, Haas HL. Histaminergic system in co-cultures of hippocampus and posterior hypothalamus: a morphological and electrophysiological study in the rat. European J Neuroscience 1997, 9: 2406-2413. 
  • Gawrisch E, Leonhardt R, Büsselberg D. Voltage-activated calcium channel currents of rat dorsal root ganglion cells are reduced by trimethyl lead Toxicology letters 1997, 92: 117-122. Pdf
  • Kirschstein T, Büsselberg D, Treede RD. Coexpression of heat-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons. Neuroscience letters 1997, 231: 1-4. Pdf
  • Domann R, Wunder L, Büsselberg D. Lead reduces calcium entry after depo-larisation without passing the cell membrane in cultured DRG neurons: FURA-2 measurements. Cell. Molec. Neurobiol. 1997, 17/3: 305-314. 
  • Leonhardt R, Pekel M, Platt B, Haas HL, Büsselberg D. Mercury compounds reduce voltage activated ion channel currents. Metal Ions in Biology and Medicine 1996, 4: 204-206. 
  • Büsselberg D. Actions of lead on neuronal membrane currents and synaptic plasticity. Metal Ions in Biology and Medicine 1996, 4: 241-243. 
  • Büsselberg D. Calcium channels as target sites of heavy metals. Toxicology letters 1995, 82/83: 255-262. Pdf
  • Leonhardt R, Haas HL, Büsselberg D. Voltage gated calcium, potassium and sodium channel currents of rat DRG neurons are reduced by methylmercury. Naunyn Schmiedebergs Archievs of Pharmacology 1996, 354/4: 532-538. Pdf
  • Leonhardt R, Pekel M, Platt B, Haas HL, Büsselberg D. Voltage-activated calcium channel currents of rat DRG neurons are reduced by mercuric chloride (HgCl2) and methylmercury (CH3HgCl). Neurotoxicology 1996, 17/1: 85-91. Pdf
  • Platt, B, Carpenter, DO, Büsselberg, D, Reymann, KG. and G. Riedel Aluminum impairs hippocampal long-term potentiation in rats in vitro and in vivo Exp. Neurol. 1995, 134: 1-14. IF: 4.156 Pdf
  • Platt B, Haas H, Büsselberg D. Aluminium reduces glutamate-activated currents of rat hippocampal neurons. NeuroReport, 1994, 5: 2329-2332. 
  • Büsselberg D, Pekel M, Michael D, Platt B. Mercury (Hg2+) and zinc (Zn2+): Two divalent cations with different actions at voltage activated calcium channel currents. Cell. Molec. Neurobiol. 1994, 14: 675-687. 
  • Büsselberg D, Michael D, Platt B. Pb2+ reduces voltage- and NMDA-activated calcium channel currents. Cell Molec. Neurobiol 1994, 14: 711-722. 
  • Platt B, Büsselberg D. Actions of aluminum on voltage activated calcium channel currents. Cell Molec. Neurobiol 1994, 14: 819-829.
  • Platt B, Büsselberg D. Combined actions of Pb2+, Zn2+ and Al2+ on voltage activated calcium channel currents. Cel.l Molec. Neurobiol. 1994, 14: 831-840. 
  • Platt B, Haas H, Büsselberg D. Extracellular pH modulates aluminium-blockade of mammalian voltage-activated calcium channel currents. NeuroReport 1993, 4: 1251-1254. 
  • Pekel M, Platt B, Büsselberg D. Effects of mercury (Hg2+) on voltage activated calcium channel currents in Aplysia and cultured rat neurons. Brain Res. 1993, 632: 121-126. Pdf
  • Büsselberg D, Platt B, Michael D, Carpenter DO, Haas HL. Mammalian voltage activated calcium channel currents are blocked by Pb2+, Zn2+ and Al2+. J Neurophysiology 1994, 71: 1491-1497. 
  • Büsselberg D, Platt B, Haas HL, Carpenter DO. Voltage-gated calcium channel currents of rat dorsal root ganglion (DRG) cells are blocked by Al2+. Brain Res. 1993, 622:163-168. Pdf
  • Uteshev V, Büsselberg D, Haas HL. Pb2+ modulates the NMDA-receptor-channel complex. Naunyn Schmiedebergs Archiv of Pharmacology, 1993, 347:209-213. 
  • Hori N, Büsselberg D, Matthews R, Parson P, Carpenter DO. Lead blocks LTP by an action not at NMDA receptors. J Experimental Neurology, 1993, 119:192-197. Pdf
  • Büsselberg D, Evans M L, Haas H L, Carpenter DO. Blockade of mammalian and invertebrate calcium channels by lead Neurotoxicology, 1993, 14:249-258. 
  • Büsselberg D, Michael D, Evans M L, Carpenter DO, Haas HL. Zinc (Zn2+) blocks voltage gated calcium channels in cultured rat dorsal root ganglion cells. Brain Res., 1992, 593:77-81. Pdf
  • Evans M L, Büsselberg D, Carpenter D O. Lead blocks the calcium current of cultured dorsal root ganglion cells. Neuroscience letters, 1991, 129:103-106. Pdf
  • Schönrock B, Büsselberg D, Haas H L. Properties of tuberomammillary hista-mine neurones and their response to galanin. Agents and Actions, 1991, 33, 135-137. 
  • Büsselberg D, Evans M L, Rahmann H, Carpenter DO. Lead and Zinc block a voltage activated calcium channel of Aplysia neurons. J Neurophysiology, 1991, 65(4): 786-795. 
  • Büsselberg D, Evans M L, Rahmann H, Carpenter DO. Effects of inorganic and triethyllead and inorganic mercury on the voltage activated calcium channel of Aplysia neurons. Neurotoxicology, 1991, 12:733-744. 
  • Büsselberg D, Evans ML, Rahmann H, Carpenter DO. Zn2+ blocks the voltage activated calcium current of Aplysia neurons and changes its kinetics. Neuroscience letters, 1990, 117-122. Pdf
  • Büsselberg D, Evans ML, Rahmann H, Carpenter DO. Lead inhibits the voltage activated calcium current of Aplysia neurons. Toxicology letters, 1990, 51:51-57. Pdf
  • Büsselberg D, Carpenter DO, Sugita M, Araki S, Satake M, Rahmann H. Effects of exogenous lipid on excitability of Aplysia neurons. Biomedical Research, 1990, 11 (2):77-86. 
  • Büsselberg D, Evans ML, Rahmann H, Carpenter DO. Effects of exogenous gangliosides and cholesterol application of Aplysia neurons. Memb Biochem, 1989, 8:19-26. 
4. Books, Book Chapters and reviews
  • Chapter 9. Calcium ([Ca2+]i) signaling as a key-target for cancer treatment. Florea AM, Büsselberg D. Book: Calcium Signaling ISBN: 978-1-61324-313-8 Editor: Masayoshi Yamaguchi, ©2011 Nova Science Publishers, Inc.
  • Mock E P, Juntermanns B, Göpelt K, Büsselberg D. Various „drugs“ influence the respiratory rhythm. In: Neuro-Visionen 4; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2007, 39-40.
  • Hagenacker T, Ledwig D, Neuendorf A, Czeschik C, Schäfers M, Büsselberg D. New pharmaceutic interventions in the therapy of chronic pain. In: Neuro-Visionen 4; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2007, 133-135.
  • Günes DA, Florea A-M, Splettstoesser F, Kunz I, Büsselberg D. Anti-cancer drugs elevate intracellular calcium by different mechanisms. In: Neuro-Visionen 4; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2007, 35-36.
  • Neuendorf A, Hagenacker T, Büsselberg D. Differential modulation of voltage gated channels by capsaicin. In: Neuro-Visionen 3; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2006, 99-100.
  • Florea A-M, Splettstoesser F, Tomaszewski A, Büsselberg D. Anti cancer drugs (As2O3 and cis-platin) interfere with calcium signals in in tumour cells. In: Neuro-Visionen 3; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2006, 34-36.
  • Mock E P, Göpelt K, Büsselberg D. Calcium channel modulators influence breathing. In: Neuro-Visionen 3; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2006, 32-33.
  • Florea A-M, Splettstoesser F, Dopp E, Rettenmeier A W, Büsselberg D. The environmentally relevant trimethyltin (TMT) influences calcium homeostasis in ex-citable and non-excitable cell systems. In: Neuro-Visionen 2; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2005, 23-25.
  • Juntermanns B, Göpelt K, Splettstoesser F, Büsselberg D. The respiratory rhythm changes under blockade of gap junctions. In: Neuro-Visionen 2; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2005, 51-53.
  • Hagenacker T, Splettstoesser F, Büsselberg D. Pain modulation by voltage gated calcium channels. In: Neuro-Visionen 2; K.-A. Hossmann (Ed.), Verlag Ferdinand Schöningh, Paderborn, München, Wien, Zürich, 2005, 145-146.
  • Büsselberg D. Actions of Metals on Membrane Channels, Calcium Homeostasis and Synaptic Plastivity. In: Organometal and Metalloid Specism in the Environment: Analysis, Distribution, Processes and Toxicological Evaluation; A. V. Hirner & H. Emons (Eds.), Springer, Wien, New York, 2004, 259-281.
  • Büsselberg D. Blei reduziert Gedächtnisleistungen: historische und aktuelle Aspekte; Stand der Forschung. In: Kulturring, Jahresberichte, 1996, 73:18-20.
  • Haas H L, Büsselberg D. Neurotoxikologie in vitro mit Hilfe der Elektrophysiologie. In: Ersatz- und Ergänzungsmethoden zu Tierversuchen; Schöffl, H., Spielmann, H. und Tritthart, H.A., Springer, Wien, New York, 1996, 65-69.
  • Büsselberg D. Bleiwirkungen auf neuronale Membranströme und synaptische Plastizität. Habilitationsschrift; Verlag Dr. Köster, Berlin; ISBN 3-89574-064-0; 1995.
  • Haas H L, Büsselberg D. Recording Chambers - Slices. In: Practical electro-physiological methods. A guide for in vitro studies in vertebrate neurobiology; Kettenmann, H. and Grantyn R. (Eds.), Wiley-Liss, New York, 1992, p. 16-19.