Dr. Steven C. Hunt joined Weill Cornell Medicine - Qatar (WCM-Q) in October 2014 as Professor of Genetic Medicine in the Research Division.
Dr. Hunt attended the University of Utah where he obtained his B.S. in Mathematics and his Ph.D. in Genetic Epidemiology. In 1980, he was invited to join the faculty, and since 1993, served as Professor of Internal Medicine. He is trained in biostatistics, genetic epidemiology, physiology, and computer applications to biomedical research.
His research is centered around genetic and environmental causes of cardiovascular disease, particularly focusing on hypertension, lipids, and severe obesity. Relatives of probands of interest have been recruited to create extended, high-risk pedigrees for detailed phenotypic and genetic studies assessing underlying cardiovascular and obesity risk factors and disease outcomes. He directs a long-term, controlled, longitudinal study on the risks and benefits of gastric bypass surgery for the severely obese. He is working on detailed physiological studies relating gene variants and expression to salt sensitivity of blood pressure, focusing on the renin-angiotensin, cortisol, and catecholamine systems. He is also funded to look at gene expression of cardiomyocytes derived from induced pluripotent stem cells of sibships with high genetic risk of abnormal echocardiographic measurements obtained over 10 years.
Dr. Hunt has authored 300 original research peer-reviewed publications in leading journals and has presented extensively at national and international conferences. He has been a member of many national and international committees and taskforces, such as a four-year term on the NIH Cardiovascular and Sleep Epidemiology Study Section, the NIH personalized medicine RFA review group, the NHLBI mammalian genotyping (linkage markers) review committee, the NHLBI re-sequencing and genotyping service review panel, and the Eurogear review committee for the European Science Foundation. He has been a grant reviewer for NHLBI special study sections and was Chair of the NHLBI re-sequencing and genotyping service review panel from 2008 through 2010. He is a member of the American Society of Human Genetics, the American Heart Association Council on Hypertension, and the International Genetic Epidemiology Society, and is a Fellow of the Obesity Society.
- Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, LaMonte MJ, Stroup AM, Hunt SC. Long-Term Mortality After Gastric Bypass Surgery. NEJM 2007;357:753-761. PMID=17715409
- Levy D, Neuhausen SL, Hunt SC, Kimura M, Hwang SJ, Chen W, Bis JC, Fitzpatrick AL, Smith E, Johnson AD, Gardner JP, Srinivasan SR, Schork N, Rotter JI, Herbig U, Psaty BM, Sastrasinh M, Murray SS, Vasan RS, Province MA, Glazer NL, Lu X, Cao X, Kronmal R, Mangino M, Soranzo N, Spector TD, Berenson GS, Aviv A. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9293-8. PMID:20421499, PMCID:2889047.
- Hunt SC, Hasstedt SJ, Xin Y, Dalley BK, Milash B, Yakobson E, Gress RE, Davidson LE, Adams TD. Polymorphisms in the NPY2R Gene Show Significant Associations with BMI that are Additive to FTO, MC4R, and NPFFR2 Gene Effects. Obesity 2011; 11:2241-7. PMID: 21818152
- The International Consortium for Blood Pressure Genome-Wide Association Studies. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011; 478:103-9. PMID:21909115.
- Adams TD, Davidson LE, Litwin SE, Kolotkin RL, LaMonte MJ, Pendleton RC, Strong MB, Vinik R, Wanner NA, Hopkins PN, Gress RE, Walker JM, Cloward TV, Nuttall T, Hammoud A, Greenwood JLJ, Crosby RD, McKinlay R, Simper SC, Smith SC, Hunt SC. Health Benefits of Gastric Bypass Surgery after Six Years. JAMA 2012; 308:1122-1131. PMID: 22990271; PMCID: PMC3744888.
- Aston KI, Hunt SC, Susser E, Kimura M, Factor-Litvak P, Carrell D, Aviv A. Divergence of Sperm and Leukocyte Age-Dependent Telomere Dynamics: Implications for Male-Driven Evolution of Telomere Length in Humans. Mol Hum Reprod 2012; 18(11):517-22. PMID: 22782639; PMCID: PMC3480822,
- Do R, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013;45:1345-52. PMID: 24097064.
- Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2014; (in press).