APR 28 - APR 29 2018 AT INTERCONTINENTAL DOHA


Signaling at Membrane Contact Sites

ADVANCING DISCOVERY IN CELL SIGNALING

Stefan Feske, MD

Stefan Feske

Associate Professor, Department of Pathology
Member, Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York University School of Medicine
New York, NY, USA

Stefan Feske is an Associate Professor in the Department of Pathology at the New York University School of Medicine, New York, USA. He graduated summa cum laude with an M.D. from the University of Freiburg, Germany, followed by a residency in rheumatology at the University Hospital Freiburg and research at the Max-Planck-Institute for Immunobiology in Freiburg. He conducted his postdoctoral studies at Harvard Medical School, Boston, USA, where he studied Ca2+ and NFAT signaling in lymphocyte function and immunodeficiency. He made essential contributions to the discovery of ORAI1, the CRAC channel pore subunit, and identified the first patients with CRAC channelopathy due to mutations in ORAI1 and STIM1 genes. For his work on immunodeficiency and the discovery of ORAI1, Dr. Feske received the Georges-Koehler Award from the German Immunology Society in 2007. He joined the faculty of NYUSoM in 2007. Research in his lab is focused on understanding the mechanisms regulating the function of CRAC channels and their role in cells of the immune system. He demonstrated that CRAC channels are essential for immunity to infection and antitumor immunity, but that they also mediate autoimmunity in animal models of diseases including Multiple Sclerosis and colitis. Besides CRAC channels, Dr. Feske's lab investigates which ion channels control immune responses in health and disease with the ultimate goal to identify drug targets for immunotherapy.